Design of chimeric antigen receptors with integrated controllable transient functions

The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is a key feature to improve safety. Here, we describe the development of a new CAR architecture with an integrated switch-on system that permits to control the CAR T-cell function. This system offers t...

Descripción completa

Detalles Bibliográficos
Autores principales: Juillerat, Alexandre, Marechal, Alan, Filhol, Jean-Marie, Valton, Julien, Duclert, Aymeric, Poirot, Laurent, Duchateau, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707440/
https://www.ncbi.nlm.nih.gov/pubmed/26750734
http://dx.doi.org/10.1038/srep18950
_version_ 1782409312319045632
author Juillerat, Alexandre
Marechal, Alan
Filhol, Jean-Marie
Valton, Julien
Duclert, Aymeric
Poirot, Laurent
Duchateau, Philippe
author_facet Juillerat, Alexandre
Marechal, Alan
Filhol, Jean-Marie
Valton, Julien
Duclert, Aymeric
Poirot, Laurent
Duchateau, Philippe
author_sort Juillerat, Alexandre
collection PubMed
description The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is a key feature to improve safety. Here, we describe the development of a new CAR architecture with an integrated switch-on system that permits to control the CAR T-cell function. This system offers the advantage of a transient CAR T-cell for safety while letting open the possibility of multiple cytotoxicity cycles using a small molecule drug.
format Online
Article
Text
id pubmed-4707440
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-47074402016-01-20 Design of chimeric antigen receptors with integrated controllable transient functions Juillerat, Alexandre Marechal, Alan Filhol, Jean-Marie Valton, Julien Duclert, Aymeric Poirot, Laurent Duchateau, Philippe Sci Rep Article The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is a key feature to improve safety. Here, we describe the development of a new CAR architecture with an integrated switch-on system that permits to control the CAR T-cell function. This system offers the advantage of a transient CAR T-cell for safety while letting open the possibility of multiple cytotoxicity cycles using a small molecule drug. Nature Publishing Group 2016-01-11 /pmc/articles/PMC4707440/ /pubmed/26750734 http://dx.doi.org/10.1038/srep18950 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Juillerat, Alexandre
Marechal, Alan
Filhol, Jean-Marie
Valton, Julien
Duclert, Aymeric
Poirot, Laurent
Duchateau, Philippe
Design of chimeric antigen receptors with integrated controllable transient functions
title Design of chimeric antigen receptors with integrated controllable transient functions
title_full Design of chimeric antigen receptors with integrated controllable transient functions
title_fullStr Design of chimeric antigen receptors with integrated controllable transient functions
title_full_unstemmed Design of chimeric antigen receptors with integrated controllable transient functions
title_short Design of chimeric antigen receptors with integrated controllable transient functions
title_sort design of chimeric antigen receptors with integrated controllable transient functions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707440/
https://www.ncbi.nlm.nih.gov/pubmed/26750734
http://dx.doi.org/10.1038/srep18950
work_keys_str_mv AT juilleratalexandre designofchimericantigenreceptorswithintegratedcontrollabletransientfunctions
AT marechalalan designofchimericantigenreceptorswithintegratedcontrollabletransientfunctions
AT filholjeanmarie designofchimericantigenreceptorswithintegratedcontrollabletransientfunctions
AT valtonjulien designofchimericantigenreceptorswithintegratedcontrollabletransientfunctions
AT duclertaymeric designofchimericantigenreceptorswithintegratedcontrollabletransientfunctions
AT poirotlaurent designofchimericantigenreceptorswithintegratedcontrollabletransientfunctions
AT duchateauphilippe designofchimericantigenreceptorswithintegratedcontrollabletransientfunctions

Ejemplares similares