Design of chimeric antigen receptors with integrated controllable transient functions

The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is a key feature to improve safety. Here, we describe the development of a new CAR architecture with an integrated switch-on system that permits to control the CAR T-cell function. This system offers t...

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Detalles Bibliográficos
Autores principales: Juillerat, Alexandre, Marechal, Alan, Filhol, Jean-Marie, Valton, Julien, Duclert, Aymeric, Poirot, Laurent, Duchateau, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707440/
https://www.ncbi.nlm.nih.gov/pubmed/26750734
http://dx.doi.org/10.1038/srep18950

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