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Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis

The previously reported association between fatherhood status and prostate cancer risk was controversial. We carried out the present meta-analysis of all relevant studies to summarize evidence on this association. A comprehensive literature search of studies was performed in PubMed, Web of Science,...

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Autores principales: Mao, Yeqing, Xu, Xin, Zheng, Xiangyi, Xie, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707492/
https://www.ncbi.nlm.nih.gov/pubmed/26752096
http://dx.doi.org/10.1038/srep19210
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author Mao, Yeqing
Xu, Xin
Zheng, Xiangyi
Xie, Liping
author_facet Mao, Yeqing
Xu, Xin
Zheng, Xiangyi
Xie, Liping
author_sort Mao, Yeqing
collection PubMed
description The previously reported association between fatherhood status and prostate cancer risk was controversial. We carried out the present meta-analysis of all relevant studies to summarize evidence on this association. A comprehensive literature search of studies was performed in PubMed, Web of Science, and the Chinese National Knowledge Infrastructure (CNKI) databases, covering all the papers published from their inception to September 2015. The combined risk estimates with 95% confidence intervals (CIs) were calculated using a random effects model. Heterogeneity and publication bias were also evaluated. A total of 11 studies were finally included in this meta-analysis. We found a significantly reduced risk of prostate cancer associated with being childless (OR 0.91, 95% CI 0.87–0.96). There was statistically significant heterogeneity across the studies (P < 0.001, I(2) = 88.2%). In summary, this meta-analysis supports that being fatherless is associated with a lower risk of prostate cancer. Because of the substantial heterogeneity and residual confounding, using other study designs to further explore this association and the underling mechanism is warranted.
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spelling pubmed-47074922016-01-20 Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis Mao, Yeqing Xu, Xin Zheng, Xiangyi Xie, Liping Sci Rep Article The previously reported association between fatherhood status and prostate cancer risk was controversial. We carried out the present meta-analysis of all relevant studies to summarize evidence on this association. A comprehensive literature search of studies was performed in PubMed, Web of Science, and the Chinese National Knowledge Infrastructure (CNKI) databases, covering all the papers published from their inception to September 2015. The combined risk estimates with 95% confidence intervals (CIs) were calculated using a random effects model. Heterogeneity and publication bias were also evaluated. A total of 11 studies were finally included in this meta-analysis. We found a significantly reduced risk of prostate cancer associated with being childless (OR 0.91, 95% CI 0.87–0.96). There was statistically significant heterogeneity across the studies (P < 0.001, I(2) = 88.2%). In summary, this meta-analysis supports that being fatherless is associated with a lower risk of prostate cancer. Because of the substantial heterogeneity and residual confounding, using other study designs to further explore this association and the underling mechanism is warranted. Nature Publishing Group 2016-01-11 /pmc/articles/PMC4707492/ /pubmed/26752096 http://dx.doi.org/10.1038/srep19210 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Mao, Yeqing
Xu, Xin
Zheng, Xiangyi
Xie, Liping
Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis
title Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis
title_full Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis
title_fullStr Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis
title_full_unstemmed Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis
title_short Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis
title_sort reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707492/
https://www.ncbi.nlm.nih.gov/pubmed/26752096
http://dx.doi.org/10.1038/srep19210
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