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LEGO: a novel method for gene set over-representation analysis by incorporating network-based gene weights
Pathway or gene set over-representation analysis (ORA) has become a routine task in functional genomics studies. However, currently widely used ORA tools employ statistical methods such as Fisher’s exact test that reduce a pathway into a list of genes, ignoring the constitutive functional non-equiva...
Autores principales: | Dong, Xinran, Hao, Yun, Wang, Xiao, Tian, Weidong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707541/ https://www.ncbi.nlm.nih.gov/pubmed/26750448 http://dx.doi.org/10.1038/srep18871 |
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