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Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum

Invertebrates can be primed to enhance their protection against pathogens they have encountered before. This enhanced immunity can be passed maternally or paternally to the offspring and is known as transgenerational immune priming. We challenged larvae of the red flour beetle Tribolium castaneum by...

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Autores principales: Knorr, Eileen, Schmidtberg, Henrike, Arslan, Derya, Bingsohn, Linda, Vilcinskas, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707703/
https://www.ncbi.nlm.nih.gov/pubmed/26701756
http://dx.doi.org/10.1098/rsbl.2015.0885
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author Knorr, Eileen
Schmidtberg, Henrike
Arslan, Derya
Bingsohn, Linda
Vilcinskas, Andreas
author_facet Knorr, Eileen
Schmidtberg, Henrike
Arslan, Derya
Bingsohn, Linda
Vilcinskas, Andreas
author_sort Knorr, Eileen
collection PubMed
description Invertebrates can be primed to enhance their protection against pathogens they have encountered before. This enhanced immunity can be passed maternally or paternally to the offspring and is known as transgenerational immune priming. We challenged larvae of the red flour beetle Tribolium castaneum by feeding them on diets supplemented with Escherichia coli, Micrococcus luteus or Pseudomonas entomophila, thus mimicking natural exposure to pathogens. The oral uptake of bacteria induced immunity-related genes in the offspring, but did not affect the methylation status of the egg DNA. However, we observed the translocation of bacteria or bacterial fragments from the gut to the developing eggs via the female reproductive system. Such translocating microbial elicitors are postulated to trigger bacterial strain-specific immune responses in the offspring and provide an alternative mechanistic explanation for maternal transgenerational immune priming in coleopteran insects.
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spelling pubmed-47077032016-01-22 Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum Knorr, Eileen Schmidtberg, Henrike Arslan, Derya Bingsohn, Linda Vilcinskas, Andreas Biol Lett Physiology Invertebrates can be primed to enhance their protection against pathogens they have encountered before. This enhanced immunity can be passed maternally or paternally to the offspring and is known as transgenerational immune priming. We challenged larvae of the red flour beetle Tribolium castaneum by feeding them on diets supplemented with Escherichia coli, Micrococcus luteus or Pseudomonas entomophila, thus mimicking natural exposure to pathogens. The oral uptake of bacteria induced immunity-related genes in the offspring, but did not affect the methylation status of the egg DNA. However, we observed the translocation of bacteria or bacterial fragments from the gut to the developing eggs via the female reproductive system. Such translocating microbial elicitors are postulated to trigger bacterial strain-specific immune responses in the offspring and provide an alternative mechanistic explanation for maternal transgenerational immune priming in coleopteran insects. The Royal Society 2015-12 /pmc/articles/PMC4707703/ /pubmed/26701756 http://dx.doi.org/10.1098/rsbl.2015.0885 Text en © 2015 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Physiology
Knorr, Eileen
Schmidtberg, Henrike
Arslan, Derya
Bingsohn, Linda
Vilcinskas, Andreas
Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum
title Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum
title_full Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum
title_fullStr Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum
title_full_unstemmed Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum
title_short Translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in Tribolium castaneum
title_sort translocation of bacteria from the gut to the eggs triggers maternal transgenerational immune priming in tribolium castaneum
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707703/
https://www.ncbi.nlm.nih.gov/pubmed/26701756
http://dx.doi.org/10.1098/rsbl.2015.0885
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