Cargando…
Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus
Staphylococcus aureus is the leading cause of many human infectious diseases. Besides infectious dangers, S. aureus is well-known for the quickly developed drug resistance. Although great efforts have been made, mechanisms underlying the antibiotic effects of S. aureus are still not well clarified....
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708009/ https://www.ncbi.nlm.nih.gov/pubmed/26424697 http://dx.doi.org/10.1042/BSR20140167 |
_version_ | 1782409387731582976 |
---|---|
author | Li, Gui-qiu Quan, Feng Qu, Ting Lu, Juan Chen, Shu-lan Cui, Lan-ying Guo, Da-wen Wang, Yong-chen |
author_facet | Li, Gui-qiu Quan, Feng Qu, Ting Lu, Juan Chen, Shu-lan Cui, Lan-ying Guo, Da-wen Wang, Yong-chen |
author_sort | Li, Gui-qiu |
collection | PubMed |
description | Staphylococcus aureus is the leading cause of many human infectious diseases. Besides infectious dangers, S. aureus is well-known for the quickly developed drug resistance. Although great efforts have been made, mechanisms underlying the antibiotic effects of S. aureus are still not well clarified. Recently, reports have shown that oxidative stress connects with bactericidal antibiotics [Dwyer et al. (2009) Curr. Opin. Microbiol. 12, 482–489]. Based on this point, we demonstrate that reactive oxygen species (ROS) induced by sublethal vancomycin may be partly responsible for the antibiotic resistance in heterogeneous vancomycin resistant S. aureus (hVRSA). Sublethal vancomycin treatment may induce protective ROS productions in hVRSA, whereas reduction in ROS level in hVRSA strains may increase their vancomycin susceptibility. Moreover, low dose of ROS in VSSA (vancomycin susceptible S. aureus) strains may promote their survival under vancomycin conditions. Our findings reveal that modest ROS generation may be protective for vancomycin resistance in hVRSA. These results recover novel insights into the relationship between oxidative stress and bacterial resistance, which has important applications for further use of antibiotics and development of therapeutics strategies for hVRSA. |
format | Online Article Text |
id | pubmed-4708009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47080092016-02-02 Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus Li, Gui-qiu Quan, Feng Qu, Ting Lu, Juan Chen, Shu-lan Cui, Lan-ying Guo, Da-wen Wang, Yong-chen Biosci Rep Original Papers Staphylococcus aureus is the leading cause of many human infectious diseases. Besides infectious dangers, S. aureus is well-known for the quickly developed drug resistance. Although great efforts have been made, mechanisms underlying the antibiotic effects of S. aureus are still not well clarified. Recently, reports have shown that oxidative stress connects with bactericidal antibiotics [Dwyer et al. (2009) Curr. Opin. Microbiol. 12, 482–489]. Based on this point, we demonstrate that reactive oxygen species (ROS) induced by sublethal vancomycin may be partly responsible for the antibiotic resistance in heterogeneous vancomycin resistant S. aureus (hVRSA). Sublethal vancomycin treatment may induce protective ROS productions in hVRSA, whereas reduction in ROS level in hVRSA strains may increase their vancomycin susceptibility. Moreover, low dose of ROS in VSSA (vancomycin susceptible S. aureus) strains may promote their survival under vancomycin conditions. Our findings reveal that modest ROS generation may be protective for vancomycin resistance in hVRSA. These results recover novel insights into the relationship between oxidative stress and bacterial resistance, which has important applications for further use of antibiotics and development of therapeutics strategies for hVRSA. Portland Press Ltd. 2015-12-24 /pmc/articles/PMC4708009/ /pubmed/26424697 http://dx.doi.org/10.1042/BSR20140167 Text en © 2015 Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) . |
spellingShingle | Original Papers Li, Gui-qiu Quan, Feng Qu, Ting Lu, Juan Chen, Shu-lan Cui, Lan-ying Guo, Da-wen Wang, Yong-chen Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus |
title | Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus |
title_full | Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus |
title_fullStr | Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus |
title_full_unstemmed | Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus |
title_short | Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus |
title_sort | sublethal vancomycin-induced ros mediating antibiotic resistance in staphylococcus aureus |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708009/ https://www.ncbi.nlm.nih.gov/pubmed/26424697 http://dx.doi.org/10.1042/BSR20140167 |
work_keys_str_mv | AT liguiqiu sublethalvancomycininducedrosmediatingantibioticresistanceinstaphylococcusaureus AT quanfeng sublethalvancomycininducedrosmediatingantibioticresistanceinstaphylococcusaureus AT quting sublethalvancomycininducedrosmediatingantibioticresistanceinstaphylococcusaureus AT lujuan sublethalvancomycininducedrosmediatingantibioticresistanceinstaphylococcusaureus AT chenshulan sublethalvancomycininducedrosmediatingantibioticresistanceinstaphylococcusaureus AT cuilanying sublethalvancomycininducedrosmediatingantibioticresistanceinstaphylococcusaureus AT guodawen sublethalvancomycininducedrosmediatingantibioticresistanceinstaphylococcusaureus AT wangyongchen sublethalvancomycininducedrosmediatingantibioticresistanceinstaphylococcusaureus |