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Medical treatment of male infertility
The majority of male infertility is idiopathic. However, there are multiple known causes of male infertility, and some of these causes can be treated medically with high success rates. In cases of idiopathic or genetic causes of male infertility, medical management is typically empirical; in most in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708300/ https://www.ncbi.nlm.nih.gov/pubmed/26816749 http://dx.doi.org/10.3978/j.issn.2223-4683.2014.01.06 |
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author | Dabaja, Ali A. Schlegel, Peter N. |
author_facet | Dabaja, Ali A. Schlegel, Peter N. |
author_sort | Dabaja, Ali A. |
collection | PubMed |
description | The majority of male infertility is idiopathic. However, there are multiple known causes of male infertility, and some of these causes can be treated medically with high success rates. In cases of idiopathic or genetic causes of male infertility, medical management is typically empirical; in most instances medical therapy represents off-label use that is not specifically approved by the FDA. Understanding the hypothalamic-pituitary-gonadal (HPG) axis and the effect of estrogen excess is critical for the assessment and treatment of male infertility. The use of certain medical treatment has been associated with an increase in sperm production or motility, and primarily focuses on optimizing testosterone (T) production from the Leydig cells, increasing follicle-stimulating hormone (FSH) levels to stimulate Sertoli cells and spermatogenesis, and normalizing the T to estrogen ratio. |
format | Online Article Text |
id | pubmed-4708300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-47083002016-01-26 Medical treatment of male infertility Dabaja, Ali A. Schlegel, Peter N. Transl Androl Urol Review Article The majority of male infertility is idiopathic. However, there are multiple known causes of male infertility, and some of these causes can be treated medically with high success rates. In cases of idiopathic or genetic causes of male infertility, medical management is typically empirical; in most instances medical therapy represents off-label use that is not specifically approved by the FDA. Understanding the hypothalamic-pituitary-gonadal (HPG) axis and the effect of estrogen excess is critical for the assessment and treatment of male infertility. The use of certain medical treatment has been associated with an increase in sperm production or motility, and primarily focuses on optimizing testosterone (T) production from the Leydig cells, increasing follicle-stimulating hormone (FSH) levels to stimulate Sertoli cells and spermatogenesis, and normalizing the T to estrogen ratio. AME Publishing Company 2014-03 /pmc/articles/PMC4708300/ /pubmed/26816749 http://dx.doi.org/10.3978/j.issn.2223-4683.2014.01.06 Text en 2014 Translational Andrology and Urology. All rights reserved. |
spellingShingle | Review Article Dabaja, Ali A. Schlegel, Peter N. Medical treatment of male infertility |
title | Medical treatment of male infertility |
title_full | Medical treatment of male infertility |
title_fullStr | Medical treatment of male infertility |
title_full_unstemmed | Medical treatment of male infertility |
title_short | Medical treatment of male infertility |
title_sort | medical treatment of male infertility |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708300/ https://www.ncbi.nlm.nih.gov/pubmed/26816749 http://dx.doi.org/10.3978/j.issn.2223-4683.2014.01.06 |
work_keys_str_mv | AT dabajaalia medicaltreatmentofmaleinfertility AT schlegelpetern medicaltreatmentofmaleinfertility |