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Medical treatment of male infertility

The majority of male infertility is idiopathic. However, there are multiple known causes of male infertility, and some of these causes can be treated medically with high success rates. In cases of idiopathic or genetic causes of male infertility, medical management is typically empirical; in most in...

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Detalles Bibliográficos
Autores principales: Dabaja, Ali A., Schlegel, Peter N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708300/
https://www.ncbi.nlm.nih.gov/pubmed/26816749
http://dx.doi.org/10.3978/j.issn.2223-4683.2014.01.06
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author Dabaja, Ali A.
Schlegel, Peter N.
author_facet Dabaja, Ali A.
Schlegel, Peter N.
author_sort Dabaja, Ali A.
collection PubMed
description The majority of male infertility is idiopathic. However, there are multiple known causes of male infertility, and some of these causes can be treated medically with high success rates. In cases of idiopathic or genetic causes of male infertility, medical management is typically empirical; in most instances medical therapy represents off-label use that is not specifically approved by the FDA. Understanding the hypothalamic-pituitary-gonadal (HPG) axis and the effect of estrogen excess is critical for the assessment and treatment of male infertility. The use of certain medical treatment has been associated with an increase in sperm production or motility, and primarily focuses on optimizing testosterone (T) production from the Leydig cells, increasing follicle-stimulating hormone (FSH) levels to stimulate Sertoli cells and spermatogenesis, and normalizing the T to estrogen ratio.
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spelling pubmed-47083002016-01-26 Medical treatment of male infertility Dabaja, Ali A. Schlegel, Peter N. Transl Androl Urol Review Article The majority of male infertility is idiopathic. However, there are multiple known causes of male infertility, and some of these causes can be treated medically with high success rates. In cases of idiopathic or genetic causes of male infertility, medical management is typically empirical; in most instances medical therapy represents off-label use that is not specifically approved by the FDA. Understanding the hypothalamic-pituitary-gonadal (HPG) axis and the effect of estrogen excess is critical for the assessment and treatment of male infertility. The use of certain medical treatment has been associated with an increase in sperm production or motility, and primarily focuses on optimizing testosterone (T) production from the Leydig cells, increasing follicle-stimulating hormone (FSH) levels to stimulate Sertoli cells and spermatogenesis, and normalizing the T to estrogen ratio. AME Publishing Company 2014-03 /pmc/articles/PMC4708300/ /pubmed/26816749 http://dx.doi.org/10.3978/j.issn.2223-4683.2014.01.06 Text en 2014 Translational Andrology and Urology. All rights reserved.
spellingShingle Review Article
Dabaja, Ali A.
Schlegel, Peter N.
Medical treatment of male infertility
title Medical treatment of male infertility
title_full Medical treatment of male infertility
title_fullStr Medical treatment of male infertility
title_full_unstemmed Medical treatment of male infertility
title_short Medical treatment of male infertility
title_sort medical treatment of male infertility
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708300/
https://www.ncbi.nlm.nih.gov/pubmed/26816749
http://dx.doi.org/10.3978/j.issn.2223-4683.2014.01.06
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