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AB108. Vascularized bone marrow transplantation with renal transplantation

Since the first case of kidney transplant succeeded in 1954, the technology is relatively mature in renal transplant. After operation one year and five years of survival rate can reach more than 90% and 80%, respectively. But it still has to face rejection. The traditional way is to apply immune inh...

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Detalles Bibliográficos
Autores principales: Wei, Di, Zhang, Geng, Yuan, Jianlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708484/
http://dx.doi.org/10.3978/j.issn.2223-4683.2014.s108
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author Wei, Di
Zhang, Geng
Yuan, Jianlin
author_facet Wei, Di
Zhang, Geng
Yuan, Jianlin
author_sort Wei, Di
collection PubMed
description Since the first case of kidney transplant succeeded in 1954, the technology is relatively mature in renal transplant. After operation one year and five years of survival rate can reach more than 90% and 80%, respectively. But it still has to face rejection. The traditional way is to apply immune inhibitors to prevent rejection. But the side effects brought by the immunosuppressant seriously affects patients’ quality of life. So the induction of immune tolerance has become a research hotspot. Vascularized bone marrow transplantation (VBMT) is developed on the basis of bone marrow transplantation (BMT). Its characteristic is with marrow stromal environment, which not only can provide cell nutrition, promoting cell growth, also can adjust and control function of lymphocytes. Possible explanation is that the complete bone marrow stromal cells produce different cytokines. These factors may have effects on hematopoietic stem cells, and promote their ability of proliferation differentiation. The other aspect, the bone itself is the part of the bone marrow stromal microenvironment, and osteoblast has a proliferous and differentiated effect on hematopoietic stem cells. At the same time, the bone marrow stromal cells can produce extracellular matrix, which can pass through specific surface receptors, promoting the information transfer between hematopoietic cells, stabilizing growth factor between the matrix and the hematopoietic cells. And many scholars have proved it in the unique effect of establishing the chimera and inducing immune tolerance. Therefore, we can try to build VBMT in rats model of kidney transplantation, to explore the effect of VBMT in the induction of immune tolerance in renal transplantation, and research the mechanism.
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spelling pubmed-47084842016-01-26 AB108. Vascularized bone marrow transplantation with renal transplantation Wei, Di Zhang, Geng Yuan, Jianlin Transl Androl Urol Abstract Publication Urology Since the first case of kidney transplant succeeded in 1954, the technology is relatively mature in renal transplant. After operation one year and five years of survival rate can reach more than 90% and 80%, respectively. But it still has to face rejection. The traditional way is to apply immune inhibitors to prevent rejection. But the side effects brought by the immunosuppressant seriously affects patients’ quality of life. So the induction of immune tolerance has become a research hotspot. Vascularized bone marrow transplantation (VBMT) is developed on the basis of bone marrow transplantation (BMT). Its characteristic is with marrow stromal environment, which not only can provide cell nutrition, promoting cell growth, also can adjust and control function of lymphocytes. Possible explanation is that the complete bone marrow stromal cells produce different cytokines. These factors may have effects on hematopoietic stem cells, and promote their ability of proliferation differentiation. The other aspect, the bone itself is the part of the bone marrow stromal microenvironment, and osteoblast has a proliferous and differentiated effect on hematopoietic stem cells. At the same time, the bone marrow stromal cells can produce extracellular matrix, which can pass through specific surface receptors, promoting the information transfer between hematopoietic cells, stabilizing growth factor between the matrix and the hematopoietic cells. And many scholars have proved it in the unique effect of establishing the chimera and inducing immune tolerance. Therefore, we can try to build VBMT in rats model of kidney transplantation, to explore the effect of VBMT in the induction of immune tolerance in renal transplantation, and research the mechanism. AME Publishing Company 2014-09 /pmc/articles/PMC4708484/ http://dx.doi.org/10.3978/j.issn.2223-4683.2014.s108 Text en 2014 Translational Andrology and Urology. All rights reserved.
spellingShingle Abstract Publication Urology
Wei, Di
Zhang, Geng
Yuan, Jianlin
AB108. Vascularized bone marrow transplantation with renal transplantation
title AB108. Vascularized bone marrow transplantation with renal transplantation
title_full AB108. Vascularized bone marrow transplantation with renal transplantation
title_fullStr AB108. Vascularized bone marrow transplantation with renal transplantation
title_full_unstemmed AB108. Vascularized bone marrow transplantation with renal transplantation
title_short AB108. Vascularized bone marrow transplantation with renal transplantation
title_sort ab108. vascularized bone marrow transplantation with renal transplantation
topic Abstract Publication Urology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708484/
http://dx.doi.org/10.3978/j.issn.2223-4683.2014.s108
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