AB226. The effects of transrectal radiofrequency hyperthermia on patients with chronic prostatitis and the changes of IL-8, IL-10, TNF-α, PGE2, β2-endorphin levels in pre-treatment and post-treatment

OBJECTIVE: To assess the effectiveness of transrectal radiofrequency hyperthermia in men with chronic prostatitis (CP), and explore the changes of IL-8, IL-10, TNF-equency hyperthermia in men wi CP patients pre-treatment and post-treatment. MATERIALS AND METHODS: Patients diagnosed with chronic prostatitis were randomized to 6 weeks of tamsulosin plus clarithromycin, transrectal radiofrequency hyperthermia (TRFH) or TRFH with tamsulosin plus clarithromycin group, respectively. The primary outcome measure was evaluated by the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). The expression of EPS interleukin-8 (IL-8), interleukin 10 (IL-10), tumor necrosis factor (TNF-α), prostaglandin E2 (PGE2) and β2-endorphin (βNIH-) were detected by ELISA in the pre-treatment and post-treatment of CP. RESULTS: A total of 159 patients were randomized in the study. The NIH-CPSI total, domain and pain scores significantly decreased from baseline in all groups, After treatment, IL-8 and IL-10 was significantly decreased in the TRFH with tamsulosin plus clarithromycin group compared to the other two groups(P<0.05), Among the three groups, there was no significant changes of TNF-, domain and pain scores significantly, the levels of PGE2 was significantly decreased (P<0.05), while the TNF-, domain and pain scores significantly decreased from baseline in all groin plus clarithromycin group compared to the tamsulosin plus clarithromycin group (P<0.05). In the CP patients, the results showed that there was a significant negative correlation between β2-EP and pain (r=–0.747, P<0.05) or QoL (r=–0.595, P<0.05), while there was a significant positive correlation between TNF-α and micturition (r=0.619, P<0.05) or QoL (r=0.663, P<0.05), between PGE2 and pain (r=0.650, P<0.05) or QoL (r=0.685, P<0.05). CONCLUSIONS: Comparison with pre-treatment, differences in IL-8, IL-10, TNF-ɑ,PGE2 and with pre-treatment, differences in IL-8, IL-10, TNF-ɑn TNF-α and micturition in scores significantly decreased from baseline in all groin plus clarithromy effects of TRFH with tamsulosin plus clarithromycin group are superior to the TRFH group or the tamsulosin plus clarithromycin group alone.