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Intravesical liposome drug delivery and IC/BPS
Intravesical therapy has previously shown to be effective in delaying or preventing recurrence of superficial bladder cancer. This local route of drug administration is now demonstrating promise in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) with the benefit of minimal syst...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708561/ https://www.ncbi.nlm.nih.gov/pubmed/26816855 http://dx.doi.org/10.3978/j.issn.2223-4683.2015.08.03 |
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author | Janicki, Joseph J. Gruber, Michele A. Chancellor, Michael B. |
author_facet | Janicki, Joseph J. Gruber, Michele A. Chancellor, Michael B. |
author_sort | Janicki, Joseph J. |
collection | PubMed |
description | Intravesical therapy has previously shown to be effective in delaying or preventing recurrence of superficial bladder cancer. This local route of drug administration is now demonstrating promise in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) with the benefit of minimal systemic side effects. Liposomes (LPs) are lipid vesicles composed of phospholipid bilayers surrounding an aqueous core. They can incorporate drug molecules, both hydrophobic and hydrophilic, and vastly improve cellular uptake of these drug molecules via endocytosis. Intravesical LPs have therapeutic effects on IC/BPS patients, mainly due to their ability to form a protective lipid film on the urothelial surface and repair the damaged urothelium. This review considers the current status of intravesical LPs and LP mediated drug delivery for the treatment of IC/BPS. |
format | Online Article Text |
id | pubmed-4708561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-47085612016-01-26 Intravesical liposome drug delivery and IC/BPS Janicki, Joseph J. Gruber, Michele A. Chancellor, Michael B. Transl Androl Urol Review Article Intravesical therapy has previously shown to be effective in delaying or preventing recurrence of superficial bladder cancer. This local route of drug administration is now demonstrating promise in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) with the benefit of minimal systemic side effects. Liposomes (LPs) are lipid vesicles composed of phospholipid bilayers surrounding an aqueous core. They can incorporate drug molecules, both hydrophobic and hydrophilic, and vastly improve cellular uptake of these drug molecules via endocytosis. Intravesical LPs have therapeutic effects on IC/BPS patients, mainly due to their ability to form a protective lipid film on the urothelial surface and repair the damaged urothelium. This review considers the current status of intravesical LPs and LP mediated drug delivery for the treatment of IC/BPS. AME Publishing Company 2015-10 /pmc/articles/PMC4708561/ /pubmed/26816855 http://dx.doi.org/10.3978/j.issn.2223-4683.2015.08.03 Text en 2015 Translational Andrology and Urology. All rights reserved. |
spellingShingle | Review Article Janicki, Joseph J. Gruber, Michele A. Chancellor, Michael B. Intravesical liposome drug delivery and IC/BPS |
title | Intravesical liposome drug delivery and IC/BPS |
title_full | Intravesical liposome drug delivery and IC/BPS |
title_fullStr | Intravesical liposome drug delivery and IC/BPS |
title_full_unstemmed | Intravesical liposome drug delivery and IC/BPS |
title_short | Intravesical liposome drug delivery and IC/BPS |
title_sort | intravesical liposome drug delivery and ic/bps |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708561/ https://www.ncbi.nlm.nih.gov/pubmed/26816855 http://dx.doi.org/10.3978/j.issn.2223-4683.2015.08.03 |
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