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The role of Randall plaques on kidney stone formation

Randall’s plaque is microscopically a plaque of calcium deposited in the interstitial tissue of the renal papilla. These plaques are thought to serve as a nidus for urinary stone formation. Large amounts of Randall’s plaque are unique to idiopathic calcium oxalate stone formers. Although Randall’s p...

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Autor principal: Chung, Hsiao-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708577/
https://www.ncbi.nlm.nih.gov/pubmed/26816774
http://dx.doi.org/10.3978/j.issn.2223-4683.2014.07.03
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author Chung, Hsiao-Jen
author_facet Chung, Hsiao-Jen
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description Randall’s plaque is microscopically a plaque of calcium deposited in the interstitial tissue of the renal papilla. These plaques are thought to serve as a nidus for urinary stone formation. Large amounts of Randall’s plaque are unique to idiopathic calcium oxalate stone formers. Although Randall’s plaques can be found in other stone formers, only in idiopathic calcium oxalate stone formers, the detailed mechanism of stone overgrow on plaque was thoroughly studied. Calcification is invariably located in the basement membrane of the loops of Henle and from there plaques spread through the interstitium toward urothelium. Within the basement membrane, mineral deposits are individual laminated particles in which zones of crystal and organic matrix overlay each other. In the interstitium, the particles appear to fuse on the collagen bundles to form a syncytium of crystal islands in an organic sea. By loss of integrity of urothelium, regions of plaque are exposed to urine. The exposed surface will touch and be covered by molecules of urine origin, including osteopontin, Tamm Horsfall protein, and crystals formed under urine supersaturations, resulting in a ribbon of alternating matrix and crystal. Eventually crystallization escapes from matrix modulation and crystals extend outward into the space of urine and begin to form a calcium oxalate stone proper. Randall’s plaque plays an important role and is prerequisite of kidney stone formation in idiopathic calcium oxalate stone formers.
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spelling pubmed-47085772016-01-26 The role of Randall plaques on kidney stone formation Chung, Hsiao-Jen Transl Androl Urol Review Article Randall’s plaque is microscopically a plaque of calcium deposited in the interstitial tissue of the renal papilla. These plaques are thought to serve as a nidus for urinary stone formation. Large amounts of Randall’s plaque are unique to idiopathic calcium oxalate stone formers. Although Randall’s plaques can be found in other stone formers, only in idiopathic calcium oxalate stone formers, the detailed mechanism of stone overgrow on plaque was thoroughly studied. Calcification is invariably located in the basement membrane of the loops of Henle and from there plaques spread through the interstitium toward urothelium. Within the basement membrane, mineral deposits are individual laminated particles in which zones of crystal and organic matrix overlay each other. In the interstitium, the particles appear to fuse on the collagen bundles to form a syncytium of crystal islands in an organic sea. By loss of integrity of urothelium, regions of plaque are exposed to urine. The exposed surface will touch and be covered by molecules of urine origin, including osteopontin, Tamm Horsfall protein, and crystals formed under urine supersaturations, resulting in a ribbon of alternating matrix and crystal. Eventually crystallization escapes from matrix modulation and crystals extend outward into the space of urine and begin to form a calcium oxalate stone proper. Randall’s plaque plays an important role and is prerequisite of kidney stone formation in idiopathic calcium oxalate stone formers. AME Publishing Company 2014-09 /pmc/articles/PMC4708577/ /pubmed/26816774 http://dx.doi.org/10.3978/j.issn.2223-4683.2014.07.03 Text en 2014 Translational Andrology and Urology. All rights reserved.
spellingShingle Review Article
Chung, Hsiao-Jen
The role of Randall plaques on kidney stone formation
title The role of Randall plaques on kidney stone formation
title_full The role of Randall plaques on kidney stone formation
title_fullStr The role of Randall plaques on kidney stone formation
title_full_unstemmed The role of Randall plaques on kidney stone formation
title_short The role of Randall plaques on kidney stone formation
title_sort role of randall plaques on kidney stone formation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708577/
https://www.ncbi.nlm.nih.gov/pubmed/26816774
http://dx.doi.org/10.3978/j.issn.2223-4683.2014.07.03
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