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In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase
In vitro antidiabetic effect of fruits and vegetables with reports as folk remedies were investigated. The antidiabetic effects were evaluated by comparing the inhibitory properties of α‐glycosidase, aldose reductase, and antioxidant activity. The results indicated that lychee extract exhibited the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708650/ https://www.ncbi.nlm.nih.gov/pubmed/26788291 http://dx.doi.org/10.1002/fsn3.243 |
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author | Wu, Tong Luo, Jiaqiang Xu, Baojun |
author_facet | Wu, Tong Luo, Jiaqiang Xu, Baojun |
author_sort | Wu, Tong |
collection | PubMed |
description | In vitro antidiabetic effect of fruits and vegetables with reports as folk remedies were investigated. The antidiabetic effects were evaluated by comparing the inhibitory properties of α‐glycosidase, aldose reductase, and antioxidant activity. The results indicated that lychee extract exhibited the best dose‐dependent inhibitory activity against α‐glycosidase with IC (50) of 10.4 mg/mL, and lemon peel extract exhibited aldose reductase inhibitory potential with IC (50) value at 3.63 mg/mL. Besides, the result also showed that the inhibitory effects of blueberry and plum against α‐glycosidase were strong among the fruits samples. Bitter gourd and eggplant demonstrated significant inhibitory potential against aldose reductase, with IC (50) values at 8.55 mg/mL and 8.06 mg/mL, respectively. The result from correlation analysis part showed that the antioxidant activities of selected fruits and vegetables were found related to their health beneficial effects, as there was positive correlations between total flavonoids content (TFC) and aldose reductase inhibitory activity (r (2) = 0.556). |
format | Online Article Text |
id | pubmed-4708650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47086502016-01-19 In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase Wu, Tong Luo, Jiaqiang Xu, Baojun Food Sci Nutr Original Research In vitro antidiabetic effect of fruits and vegetables with reports as folk remedies were investigated. The antidiabetic effects were evaluated by comparing the inhibitory properties of α‐glycosidase, aldose reductase, and antioxidant activity. The results indicated that lychee extract exhibited the best dose‐dependent inhibitory activity against α‐glycosidase with IC (50) of 10.4 mg/mL, and lemon peel extract exhibited aldose reductase inhibitory potential with IC (50) value at 3.63 mg/mL. Besides, the result also showed that the inhibitory effects of blueberry and plum against α‐glycosidase were strong among the fruits samples. Bitter gourd and eggplant demonstrated significant inhibitory potential against aldose reductase, with IC (50) values at 8.55 mg/mL and 8.06 mg/mL, respectively. The result from correlation analysis part showed that the antioxidant activities of selected fruits and vegetables were found related to their health beneficial effects, as there was positive correlations between total flavonoids content (TFC) and aldose reductase inhibitory activity (r (2) = 0.556). John Wiley and Sons Inc. 2015-04-30 /pmc/articles/PMC4708650/ /pubmed/26788291 http://dx.doi.org/10.1002/fsn3.243 Text en © 2015 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Wu, Tong Luo, Jiaqiang Xu, Baojun In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase |
title | In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase |
title_full | In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase |
title_fullStr | In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase |
title_full_unstemmed | In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase |
title_short | In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase |
title_sort | in vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708650/ https://www.ncbi.nlm.nih.gov/pubmed/26788291 http://dx.doi.org/10.1002/fsn3.243 |
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