Cargando…
AB192. Efficacy and safety of local anaesthetics in the treatment of premature ejaculation: a systematic review and meta-analysis
OBJECTIVE: To assess the efficacy and safety of local anaesthetics for premature ejaculation (PE), a systematic review of the literature was performed using the Cochrane Library, PubMed and EMBASE. METHODS: We screened and retrieved the randomised controlled trials on the treatment of PE with local...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708710/ http://dx.doi.org/10.3978/j.issn.2223-4683.2015.s192 |
_version_ | 1782409527831822336 |
---|---|
author | Xia, Jiadong Dai, Yutian |
author_facet | Xia, Jiadong Dai, Yutian |
author_sort | Xia, Jiadong |
collection | PubMed |
description | OBJECTIVE: To assess the efficacy and safety of local anaesthetics for premature ejaculation (PE), a systematic review of the literature was performed using the Cochrane Library, PubMed and EMBASE. METHODS: We screened and retrieved the randomised controlled trials on the treatment of PE with local anaesthetics. End points included intravaginal ejaculation latency time (IELT), patient-reported outcome assessments and adverse events. Meta-analyses were conducted with STATA 11.0. RESULTS: In total, seven publications involving 566 patients with local anaesthetics and 388 with placebos strictly met our eligibility criteria. Meta-analyses showed that after the patients were treated with the local anaesthetics, the value of the standardised mean difference of the changes in IELT was 5.02 (95% CI: 3.03-7.00). A higher rate of adverse events occurred compared with placebos (odds ratio =3.30; 95% CI: 1.71-6.36), but these events were restricted to local side effects. In addition, significantly greater improvement was observed in patient-reported outcomes. CONCLUSIONS: In summary, local anaesthetics can prolong IELT and improve ejaculatory control and sexual satisfaction. |
format | Online Article Text |
id | pubmed-4708710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-47087102016-01-26 AB192. Efficacy and safety of local anaesthetics in the treatment of premature ejaculation: a systematic review and meta-analysis Xia, Jiadong Dai, Yutian Transl Androl Urol Accepted Abstracts OBJECTIVE: To assess the efficacy and safety of local anaesthetics for premature ejaculation (PE), a systematic review of the literature was performed using the Cochrane Library, PubMed and EMBASE. METHODS: We screened and retrieved the randomised controlled trials on the treatment of PE with local anaesthetics. End points included intravaginal ejaculation latency time (IELT), patient-reported outcome assessments and adverse events. Meta-analyses were conducted with STATA 11.0. RESULTS: In total, seven publications involving 566 patients with local anaesthetics and 388 with placebos strictly met our eligibility criteria. Meta-analyses showed that after the patients were treated with the local anaesthetics, the value of the standardised mean difference of the changes in IELT was 5.02 (95% CI: 3.03-7.00). A higher rate of adverse events occurred compared with placebos (odds ratio =3.30; 95% CI: 1.71-6.36), but these events were restricted to local side effects. In addition, significantly greater improvement was observed in patient-reported outcomes. CONCLUSIONS: In summary, local anaesthetics can prolong IELT and improve ejaculatory control and sexual satisfaction. AME Publishing Company 2015-08 /pmc/articles/PMC4708710/ http://dx.doi.org/10.3978/j.issn.2223-4683.2015.s192 Text en 2015 Translational Andrology and Urology. All rights reserved. |
spellingShingle | Accepted Abstracts Xia, Jiadong Dai, Yutian AB192. Efficacy and safety of local anaesthetics in the treatment of premature ejaculation: a systematic review and meta-analysis |
title | AB192. Efficacy and safety of local anaesthetics in the treatment of premature ejaculation: a systematic review and meta-analysis |
title_full | AB192. Efficacy and safety of local anaesthetics in the treatment of premature ejaculation: a systematic review and meta-analysis |
title_fullStr | AB192. Efficacy and safety of local anaesthetics in the treatment of premature ejaculation: a systematic review and meta-analysis |
title_full_unstemmed | AB192. Efficacy and safety of local anaesthetics in the treatment of premature ejaculation: a systematic review and meta-analysis |
title_short | AB192. Efficacy and safety of local anaesthetics in the treatment of premature ejaculation: a systematic review and meta-analysis |
title_sort | ab192. efficacy and safety of local anaesthetics in the treatment of premature ejaculation: a systematic review and meta-analysis |
topic | Accepted Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708710/ http://dx.doi.org/10.3978/j.issn.2223-4683.2015.s192 |
work_keys_str_mv | AT xiajiadong ab192efficacyandsafetyoflocalanaestheticsinthetreatmentofprematureejaculationasystematicreviewandmetaanalysis AT daiyutian ab192efficacyandsafetyoflocalanaestheticsinthetreatmentofprematureejaculationasystematicreviewandmetaanalysis |