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AB134. A reassessment of penile sensory pathways and effects of prilocaine-lidocaine cream in primary premature ejaculation

OBJECTIVE: To assess the penile sensory pathway abnormalities of the patients with primary premature ejaculation (PPE) and effects of prilocaine-lidocaine (PLA) cream. METHODS: we enrolled 82 PPE patients and 34 normally potent male volunteers. Somatosensory evoked potentials of dorsal nerve (DNSEP)...

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Autores principales: Xia, Jiadong, Dai, Yutian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708728/
http://dx.doi.org/10.3978/j.issn.2223-4683.2015.s134
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author Xia, Jiadong
Dai, Yutian
author_facet Xia, Jiadong
Dai, Yutian
author_sort Xia, Jiadong
collection PubMed
description OBJECTIVE: To assess the penile sensory pathway abnormalities of the patients with primary premature ejaculation (PPE) and effects of prilocaine-lidocaine (PLA) cream. METHODS: we enrolled 82 PPE patients and 34 normally potent male volunteers. Somatosensory evoked potentials of dorsal nerve (DNSEP) and glans penis (GPSEP) were performed in each subject. In addition, among the 82 patients, 60 were selected and randomly divided into PLA and placebo group, each with 30 patients. Cream were applied evenly on the glans penis with ten minutes and washed off just before DNSEP and GPSEP were repeatedly measured. RESULTS: Mean latencies of DNSEP and GPSPE were both remarkably shorter in the patients than those in the normal potent men (P<0.001, both). Compared with the control group, mean amplitudes of GPSEP were significantly greater in the patient group (P<0.001), but not considerably on the amplitudes of DNSEP (P=0.229). After cream application, the latencies and amplitudes of both DNSEP and GPSEP were significantly prolonged and reduced respectively in the active group (P<0.001, all). CONCLUSIONS: These results showed that hyperexcitable ejaculatory reflex neurological factor was linked to PPE, because of hypersensitivity of the penile, accelerated conduction, and cortical amplification of the genital stimuli. The PLA cream could delay sensory latency and decrease glans penile hyperexcitability, which may be the mechanism for PPE treatment.
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spelling pubmed-47087282016-01-26 AB134. A reassessment of penile sensory pathways and effects of prilocaine-lidocaine cream in primary premature ejaculation Xia, Jiadong Dai, Yutian Transl Androl Urol Moderated Poster Presentation OBJECTIVE: To assess the penile sensory pathway abnormalities of the patients with primary premature ejaculation (PPE) and effects of prilocaine-lidocaine (PLA) cream. METHODS: we enrolled 82 PPE patients and 34 normally potent male volunteers. Somatosensory evoked potentials of dorsal nerve (DNSEP) and glans penis (GPSEP) were performed in each subject. In addition, among the 82 patients, 60 were selected and randomly divided into PLA and placebo group, each with 30 patients. Cream were applied evenly on the glans penis with ten minutes and washed off just before DNSEP and GPSEP were repeatedly measured. RESULTS: Mean latencies of DNSEP and GPSPE were both remarkably shorter in the patients than those in the normal potent men (P<0.001, both). Compared with the control group, mean amplitudes of GPSEP were significantly greater in the patient group (P<0.001), but not considerably on the amplitudes of DNSEP (P=0.229). After cream application, the latencies and amplitudes of both DNSEP and GPSEP were significantly prolonged and reduced respectively in the active group (P<0.001, all). CONCLUSIONS: These results showed that hyperexcitable ejaculatory reflex neurological factor was linked to PPE, because of hypersensitivity of the penile, accelerated conduction, and cortical amplification of the genital stimuli. The PLA cream could delay sensory latency and decrease glans penile hyperexcitability, which may be the mechanism for PPE treatment. AME Publishing Company 2015-08 /pmc/articles/PMC4708728/ http://dx.doi.org/10.3978/j.issn.2223-4683.2015.s134 Text en 2015 Translational Andrology and Urology. All rights reserved.
spellingShingle Moderated Poster Presentation
Xia, Jiadong
Dai, Yutian
AB134. A reassessment of penile sensory pathways and effects of prilocaine-lidocaine cream in primary premature ejaculation
title AB134. A reassessment of penile sensory pathways and effects of prilocaine-lidocaine cream in primary premature ejaculation
title_full AB134. A reassessment of penile sensory pathways and effects of prilocaine-lidocaine cream in primary premature ejaculation
title_fullStr AB134. A reassessment of penile sensory pathways and effects of prilocaine-lidocaine cream in primary premature ejaculation
title_full_unstemmed AB134. A reassessment of penile sensory pathways and effects of prilocaine-lidocaine cream in primary premature ejaculation
title_short AB134. A reassessment of penile sensory pathways and effects of prilocaine-lidocaine cream in primary premature ejaculation
title_sort ab134. a reassessment of penile sensory pathways and effects of prilocaine-lidocaine cream in primary premature ejaculation
topic Moderated Poster Presentation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708728/
http://dx.doi.org/10.3978/j.issn.2223-4683.2015.s134
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