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AB196. The long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via local antioxidative mechanism

OBJECTIVE: To clarify the antioxidation role in diabetic ED treatment by a long-term administration of PDE5I. METHODS: Three groups of Sprague-Dawley rats were utilized: group N, normal control; group D, streptozotocin (STZ) induced diabetic rats as control; group D + T, STZ induced diabetic rats by...

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Detalles Bibliográficos
Autores principales: Chen, Yun, Dai, Yutian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708767/
http://dx.doi.org/10.3978/j.issn.2223-4683.2015.s196
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author Chen, Yun
Dai, Yutian
author_facet Chen, Yun
Dai, Yutian
author_sort Chen, Yun
collection PubMed
description OBJECTIVE: To clarify the antioxidation role in diabetic ED treatment by a long-term administration of PDE5I. METHODS: Three groups of Sprague-Dawley rats were utilized: group N, normal control; group D, streptozotocin (STZ) induced diabetic rats as control; group D + T, STZ induced diabetic rats by the intragastric administration with tadalafil for 8 weeks. RESULTS: ICP/MAP ratio was significantly higher in group D + T than in group D. The levels of MDA decreased remarkably and the activities of SOD increased significantly of group D + T, compared with group D. The level of mitochondrial membrane potential of cavernous tissue of diabetic rats was partly recovered by tadalafil treatment for 8 weeks. The morphology changes of mitochondria were also ameliorated in group D + T. CONCLUSIONS: The long-term administration of tadalafil on diabetic rats is proven to partly lessen the oxidative stress lesion of the penis via a local antioxidative stress pathway. Early long-term dosages of tadalafil once daily maybe partly prevent rats from diabetic erectile dysfunction. To our knowledge, this is the first report to reveal the new mechanism on long-term treatment of tadalafil in diabetic ED.
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spelling pubmed-47087672016-01-26 AB196. The long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via local antioxidative mechanism Chen, Yun Dai, Yutian Transl Androl Urol Accepted Abstracts OBJECTIVE: To clarify the antioxidation role in diabetic ED treatment by a long-term administration of PDE5I. METHODS: Three groups of Sprague-Dawley rats were utilized: group N, normal control; group D, streptozotocin (STZ) induced diabetic rats as control; group D + T, STZ induced diabetic rats by the intragastric administration with tadalafil for 8 weeks. RESULTS: ICP/MAP ratio was significantly higher in group D + T than in group D. The levels of MDA decreased remarkably and the activities of SOD increased significantly of group D + T, compared with group D. The level of mitochondrial membrane potential of cavernous tissue of diabetic rats was partly recovered by tadalafil treatment for 8 weeks. The morphology changes of mitochondria were also ameliorated in group D + T. CONCLUSIONS: The long-term administration of tadalafil on diabetic rats is proven to partly lessen the oxidative stress lesion of the penis via a local antioxidative stress pathway. Early long-term dosages of tadalafil once daily maybe partly prevent rats from diabetic erectile dysfunction. To our knowledge, this is the first report to reveal the new mechanism on long-term treatment of tadalafil in diabetic ED. AME Publishing Company 2015-08 /pmc/articles/PMC4708767/ http://dx.doi.org/10.3978/j.issn.2223-4683.2015.s196 Text en 2015 Translational Andrology and Urology. All rights reserved.
spellingShingle Accepted Abstracts
Chen, Yun
Dai, Yutian
AB196. The long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via local antioxidative mechanism
title AB196. The long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via local antioxidative mechanism
title_full AB196. The long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via local antioxidative mechanism
title_fullStr AB196. The long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via local antioxidative mechanism
title_full_unstemmed AB196. The long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via local antioxidative mechanism
title_short AB196. The long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via local antioxidative mechanism
title_sort ab196. the long-term administration of tadalafil on stz-induced diabetic rats with erectile dysfunction via local antioxidative mechanism
topic Accepted Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708767/
http://dx.doi.org/10.3978/j.issn.2223-4683.2015.s196
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