Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice

BACKGROUND: Toll-like receptors (TLR) of the innate immune system have been closely linked with the development of atherosclerotic lesions. TLR9 is activated by unmethylated CpG motifs within ssDNA, but also by CpG motifs in nucleic acids released during vascular apoptosis and necrosis. The role of...

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Detalles Bibliográficos
Autores principales: Krogmann, Alexander O., Lüsebrink, Enzo, Steinmetz, Martin, Asdonk, Tobias, Lahrmann, Catharina, Lütjohann, Dieter, Nickenig, Georg, Zimmer, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709087/
https://www.ncbi.nlm.nih.gov/pubmed/26751387
http://dx.doi.org/10.1371/journal.pone.0146326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709087/
https://www.ncbi.nlm.nih.gov/pubmed/26751387
http://dx.doi.org/10.1371/journal.pone.0146326

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