Targeting of Proteoglycan Synthesis Pathway: A New Strategy to Counteract Excessive Matrix Proteoglycan Deposition and Transforming Growth Factor-β1-Induced Fibrotic Phenotype in Lung Fibroblasts

Stimulation of proteoglycan (PG) synthesis and deposition plays an important role in the pathophysiology of fibrosis and is an early and dominant feature of pulmonary fibrosis. Transforming growth factor-β1 (TGF-β1) is a major cytokine associated with fibrosis that induces excessive synthesis of mat...

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Detalles Bibliográficos
Autores principales: Shaukat, Irfan, Barré, Lydia, Venkatesan, Narayanan, Li, Dong, Jaquinet, Jean-Claude, Fournel-Gigleux, Sylvie, Ouzzine, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709117/
https://www.ncbi.nlm.nih.gov/pubmed/26751072
http://dx.doi.org/10.1371/journal.pone.0146499

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