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Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion

Osteoprotegerin (OPG), a decoy receptor for receptor activator of NF-κB ligand (RANKL), antagonizes RANKL’s osteoclastogenic function in bone. We previously demonstrated that systemic administration of lipopolysaccharide (LPS) to mice elevates OPG levels and reduces RANKL levels in peripheral blood....

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Detalles Bibliográficos
Autores principales: Kuroda, Yukiko, Maruyama, Kenta, Fujii, Hideki, Sugawara, Isamu, Ko, Shigeru B. H., Yasuda, Hisataka, Matsui, Hidenori, Matsuo, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709133/
https://www.ncbi.nlm.nih.gov/pubmed/26751951
http://dx.doi.org/10.1371/journal.pone.0146544