FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification ha...

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Detalles Bibliográficos
Autores principales: Scholz, Carsten C., Rodriguez, Javier, Pickel, Christina, Burr, Stephen, Fabrizio, Jacqueline-alba, Nolan, Karen A., Spielmann, Patrick, Cavadas, Miguel A. S., Crifo, Bianca, Halligan, Doug N., Nathan, James A., Peet, Daniel J., Wenger, Roland H., Von Kriegsheim, Alex, Cummins, Eoin P., Taylor, Cormac T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709136/
https://www.ncbi.nlm.nih.gov/pubmed/26752685
http://dx.doi.org/10.1371/journal.pbio.1002347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709136/
https://www.ncbi.nlm.nih.gov/pubmed/26752685
http://dx.doi.org/10.1371/journal.pbio.1002347

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