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Ultra-Deep Bisulfite Sequencing to Detect Specific DNA Methylation Patterns of Minor Cell Types in Heterogeneous Cell Populations: An Example of the Pituitary Tissue
DNA methylation is an epigenetic modification important for cell fate determination and cell type-specific gene expression. Transcriptional regulatory regions of the mammalian genome contain a large number of tissue/cell type-dependent differentially methylated regions (T-DMRs) with DNA methylation...
Autores principales: | Arai, Yoshikazu, Fukukawa, Hisho, Atozi, Takanori, Matsumoto, Shoma, Hanazono, Yutaka, Nagashima, Hiroshi, Ohgane, Jun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709138/ https://www.ncbi.nlm.nih.gov/pubmed/26752725 http://dx.doi.org/10.1371/journal.pone.0146498 |
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