The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD

INTRODUCTION: Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine associated with acute and chronic inflammatory disorders and corticosteroid insensitivity. Its expression in the airways of patients with chronic obstructive pulmonary disease (COPD), a relatively steroid insensit...

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Detalles Bibliográficos
Autores principales: Russell, Kirsty E., Chung, Kian Fan, Clarke, Colin J., Durham, Andrew L., Mallia, Patrick, Footitt, Joseph, Johnston, Sebastian L., Barnes, Peter J., Hall, Simon R., Simpson, Karen D., Starkey, Malcolm R., Hansbro, Philip M., Adcock, Ian M., Wiegman, Coen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709227/
https://www.ncbi.nlm.nih.gov/pubmed/26752192
http://dx.doi.org/10.1371/journal.pone.0146102

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