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Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma

BACKGROUND: Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5 year survival rate of 20–30 %. Various factors have been implicated in the pathogenesis of ACC including dysregulation of the G2/M transition and aberrant activity of p53 and MDM2. Polo-like kinase 1 (PLK-1) negatively modul...

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Detalles Bibliográficos
Autores principales:	Bussey, Kimberly J., Bapat, Aditi, Linnehan, Claire, Wandoloski, Melissa, Dastrup, Erica, Rogers, Erik, Gonzales, Paul, Demeure, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709336/ https://www.ncbi.nlm.nih.gov/pubmed/26754547 http://dx.doi.org/10.1186/s40169-015-0080-3

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