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Clinical experience in appendiceal neuroendocrine neoplasms

AIM OF THE STUDY: To analyse the incidence of appendiceal neuroendocrine neoplasms in appendectomy specimens and establish the epidemiological and histopathological features, treatment, and clinical course. MATERIAL AND METHODS: Between 2004 and 2013, 975 patients who underwent appendectomy in Ankar...

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Autores principales: Ozcelik, Caglar K., Turanli, Sevim, Bozdogan, Nazan, Dibekoglu, Cengiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709403/
https://www.ncbi.nlm.nih.gov/pubmed/26793027
http://dx.doi.org/10.5114/wo.2015.56008
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author Ozcelik, Caglar K.
Turanli, Sevim
Bozdogan, Nazan
Dibekoglu, Cengiz
author_facet Ozcelik, Caglar K.
Turanli, Sevim
Bozdogan, Nazan
Dibekoglu, Cengiz
author_sort Ozcelik, Caglar K.
collection PubMed
description AIM OF THE STUDY: To analyse the incidence of appendiceal neuroendocrine neoplasms in appendectomy specimens and establish the epidemiological and histopathological features, treatment, and clinical course. MATERIAL AND METHODS: Between 2004 and 2013, 975 patients who underwent appendectomy in Ankara Oncology Education and Research Hospital were retrospectively analysed. RESULTS: Neuroendocrine neoplasm was detected in the nine of 975 (0.9%) patients. Neuroendocrine neoplasms were diagnosed in eight patients by appendectomy, which was performed because of the prediagnosis of acute appendicitis, and in one patient by the suspicious mass detection during surgical procedures that were done in the appendix for a different reason. Eight of the patients’ tumours were in the tip of the appendix, and one of the patients’ tumours was at the base of appendix. Tumour size in 77.8% of patients was equal or less than 1 cm, in 22.2% patients it was 1–2 cm. There was tumour invasion in the muscularis propria layer in four patients, in the serosa layer in three patients, and in the deep mesoappendix in two patients. Patients were followed for a median of 78 months. In the follow-up of patients who were operated because of colon cancer, metachronous colon tumour evolved. This patient died due to progressive disease. Other patients are still disease-free. CONCLUSIONS: The diagnosis of neuroendocrine neoplasm is often incidentally done after appendectomy. Tumour size is important in determining the extent of disease and in the selection of the surgical method during operation.
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spelling pubmed-47094032016-01-20 Clinical experience in appendiceal neuroendocrine neoplasms Ozcelik, Caglar K. Turanli, Sevim Bozdogan, Nazan Dibekoglu, Cengiz Contemp Oncol (Pozn) Original Paper AIM OF THE STUDY: To analyse the incidence of appendiceal neuroendocrine neoplasms in appendectomy specimens and establish the epidemiological and histopathological features, treatment, and clinical course. MATERIAL AND METHODS: Between 2004 and 2013, 975 patients who underwent appendectomy in Ankara Oncology Education and Research Hospital were retrospectively analysed. RESULTS: Neuroendocrine neoplasm was detected in the nine of 975 (0.9%) patients. Neuroendocrine neoplasms were diagnosed in eight patients by appendectomy, which was performed because of the prediagnosis of acute appendicitis, and in one patient by the suspicious mass detection during surgical procedures that were done in the appendix for a different reason. Eight of the patients’ tumours were in the tip of the appendix, and one of the patients’ tumours was at the base of appendix. Tumour size in 77.8% of patients was equal or less than 1 cm, in 22.2% patients it was 1–2 cm. There was tumour invasion in the muscularis propria layer in four patients, in the serosa layer in three patients, and in the deep mesoappendix in two patients. Patients were followed for a median of 78 months. In the follow-up of patients who were operated because of colon cancer, metachronous colon tumour evolved. This patient died due to progressive disease. Other patients are still disease-free. CONCLUSIONS: The diagnosis of neuroendocrine neoplasm is often incidentally done after appendectomy. Tumour size is important in determining the extent of disease and in the selection of the surgical method during operation. Termedia Publishing House 2015-12-22 2015 /pmc/articles/PMC4709403/ /pubmed/26793027 http://dx.doi.org/10.5114/wo.2015.56008 Text en Copyright © 2015 Termedia http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Ozcelik, Caglar K.
Turanli, Sevim
Bozdogan, Nazan
Dibekoglu, Cengiz
Clinical experience in appendiceal neuroendocrine neoplasms
title Clinical experience in appendiceal neuroendocrine neoplasms
title_full Clinical experience in appendiceal neuroendocrine neoplasms
title_fullStr Clinical experience in appendiceal neuroendocrine neoplasms
title_full_unstemmed Clinical experience in appendiceal neuroendocrine neoplasms
title_short Clinical experience in appendiceal neuroendocrine neoplasms
title_sort clinical experience in appendiceal neuroendocrine neoplasms
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709403/
https://www.ncbi.nlm.nih.gov/pubmed/26793027
http://dx.doi.org/10.5114/wo.2015.56008
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