Computational analysis of prolyl hydroxylase domain-containing protein 2 (PHD2) mutations promoting polycythemia insurgence in humans

Idiopathic erythrocytosis is a rare disease characterized by an increase in red blood cell mass due to mutations in proteins of the oxygen-sensing pathway, such as prolyl hydroxylase 2 (PHD2). Here, we present a bioinformatics investigation of the pathological effect of twelve PHD2 mutations related...

Descripción completa

Detalles Bibliográficos
Autores principales: Minervini, Giovanni, Quaglia, Federica, Tosatto, Silvio CE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709589/
https://www.ncbi.nlm.nih.gov/pubmed/26754054
http://dx.doi.org/10.1038/srep18716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709589/
https://www.ncbi.nlm.nih.gov/pubmed/26754054
http://dx.doi.org/10.1038/srep18716

Ejemplares similares