IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis

The transcription factors HSF1 and p53 both modulate the stress response, thereby protecting and facilitating the recovery of stressed cells, but both have the potential to promote tumor development. Here we show that a p53 target gene, IER5, encodes an activator of HSF1. IER5 forms a ternary comple...

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Detalles Bibliográficos
Autores principales: Asano, Yoshinori, Kawase, Tatsuya, Okabe, Atsushi, Tsutsumi, Shuichi, Ichikawa, Hitoshi, Tatebe, Satoko, Kitabayashi, Issay, Tashiro, Fumio, Namiki, Hideo, Kondo, Tadashi, Semba, Kentaro, Aburatani, Hiroyuki, Taya, Yoichi, Nakagama, Hitoshi, Ohki, Rieko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709660/
https://www.ncbi.nlm.nih.gov/pubmed/26754925
http://dx.doi.org/10.1038/srep19174

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