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The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology

MicroRNA-378a (miR-378a, previously known as miR-378) is one of the small noncoding RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature strands, miR-378a-3p and miR-378a-5p, originate from the first intron of the peroxisome proliferator-activated receptor gamm...

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Autores principales: Krist, Bart, Florczyk, Urszula, Pietraszek-Gremplewicz, Katarzyna, Józkowicz, Alicja, Dulak, Jozef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709675/
https://www.ncbi.nlm.nih.gov/pubmed/26839547
http://dx.doi.org/10.1155/2015/281756
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author Krist, Bart
Florczyk, Urszula
Pietraszek-Gremplewicz, Katarzyna
Józkowicz, Alicja
Dulak, Jozef
author_facet Krist, Bart
Florczyk, Urszula
Pietraszek-Gremplewicz, Katarzyna
Józkowicz, Alicja
Dulak, Jozef
author_sort Krist, Bart
collection PubMed
description MicroRNA-378a (miR-378a, previously known as miR-378) is one of the small noncoding RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature strands, miR-378a-3p and miR-378a-5p, originate from the first intron of the peroxisome proliferator-activated receptor gamma, coactivator 1 beta (ppargc1b) gene encoding PGC-1β. Embedding in the sequence of this transcriptional regulator of oxidative energy metabolism implies involvement of miR-378a in metabolic pathways, mitochondrial energy homeostasis, and related biological processes such as muscle development, differentiation, and regeneration. On the other hand, modulating the expression of proangiogenic factors such as vascular endothelial growth factor, angiopoietin-1, or interleukin-8, influencing inflammatory reaction, and affecting tumor suppressors, such as SuFu and Fus-1, miR-378a is considered as a part of an angiogenic network in tumors. In the latter, miR-378a can evoke broader actions by enhancing cell survival, reducing apoptosis, and promoting cell migration and invasion. This review describes the current knowledge on miR-378a linking oxidative/lipid metabolism, muscle biology, and blood vessel formation.
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spelling pubmed-47096752016-02-02 The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology Krist, Bart Florczyk, Urszula Pietraszek-Gremplewicz, Katarzyna Józkowicz, Alicja Dulak, Jozef Int J Endocrinol Review Article MicroRNA-378a (miR-378a, previously known as miR-378) is one of the small noncoding RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature strands, miR-378a-3p and miR-378a-5p, originate from the first intron of the peroxisome proliferator-activated receptor gamma, coactivator 1 beta (ppargc1b) gene encoding PGC-1β. Embedding in the sequence of this transcriptional regulator of oxidative energy metabolism implies involvement of miR-378a in metabolic pathways, mitochondrial energy homeostasis, and related biological processes such as muscle development, differentiation, and regeneration. On the other hand, modulating the expression of proangiogenic factors such as vascular endothelial growth factor, angiopoietin-1, or interleukin-8, influencing inflammatory reaction, and affecting tumor suppressors, such as SuFu and Fus-1, miR-378a is considered as a part of an angiogenic network in tumors. In the latter, miR-378a can evoke broader actions by enhancing cell survival, reducing apoptosis, and promoting cell migration and invasion. This review describes the current knowledge on miR-378a linking oxidative/lipid metabolism, muscle biology, and blood vessel formation. Hindawi Publishing Corporation 2015 2015-12-29 /pmc/articles/PMC4709675/ /pubmed/26839547 http://dx.doi.org/10.1155/2015/281756 Text en Copyright © 2015 Bart Krist et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Krist, Bart
Florczyk, Urszula
Pietraszek-Gremplewicz, Katarzyna
Józkowicz, Alicja
Dulak, Jozef
The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
title The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
title_full The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
title_fullStr The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
title_full_unstemmed The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
title_short The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
title_sort role of mir-378a in metabolism, angiogenesis, and muscle biology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709675/
https://www.ncbi.nlm.nih.gov/pubmed/26839547
http://dx.doi.org/10.1155/2015/281756
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