Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex

The present study was designed to evaluate the pharmacokinetic (PK) properties of di-μ-hydroxo-bis(quercetinatooxovanadium(IV) (HOBQOV) complex, with hypoglycemic and hypolipidemic properties, in rats after a single i.p. dose of 100 mg/kg b.w. The HOBQOV complex pharmacokinetics is described by a bi...

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Detalles Bibliográficos
Autores principales: VELESCU, B.S., UIVAROSI, VALENTINA, BUZESCU, ANCA, SARBU, I, IONESCU, ECATERINA, ANUTA, VALENTINA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709704/
https://www.ncbi.nlm.nih.gov/pubmed/26793323
http://dx.doi.org/10.12865/CHSJ.40.04.06
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author VELESCU, B.S.
UIVAROSI, VALENTINA
BUZESCU, ANCA
SARBU, I
IONESCU, ECATERINA
ANUTA, VALENTINA
author_facet VELESCU, B.S.
UIVAROSI, VALENTINA
BUZESCU, ANCA
SARBU, I
IONESCU, ECATERINA
ANUTA, VALENTINA
author_sort VELESCU, B.S.
collection PubMed
description The present study was designed to evaluate the pharmacokinetic (PK) properties of di-μ-hydroxo-bis(quercetinatooxovanadium(IV) (HOBQOV) complex, with hypoglycemic and hypolipidemic properties, in rats after a single i.p. dose of 100 mg/kg b.w. The HOBQOV complex pharmacokinetics is described by a bicompartmental model and the plasma concentration decrease is described by two phases that might be correlated to the distribution and elimination processes. The obtained results suggest a PK profile of the complex suitable for a profound distribution in the animal organism with possibility of interaction with the cytosolic enzymes.
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spelling pubmed-47097042016-01-20 Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex VELESCU, B.S. UIVAROSI, VALENTINA BUZESCU, ANCA SARBU, I IONESCU, ECATERINA ANUTA, VALENTINA Curr Health Sci J Original Paper The present study was designed to evaluate the pharmacokinetic (PK) properties of di-μ-hydroxo-bis(quercetinatooxovanadium(IV) (HOBQOV) complex, with hypoglycemic and hypolipidemic properties, in rats after a single i.p. dose of 100 mg/kg b.w. The HOBQOV complex pharmacokinetics is described by a bicompartmental model and the plasma concentration decrease is described by two phases that might be correlated to the distribution and elimination processes. The obtained results suggest a PK profile of the complex suitable for a profound distribution in the animal organism with possibility of interaction with the cytosolic enzymes. Medical University Publishing House Craiova 2014 2014-12-14 /pmc/articles/PMC4709704/ /pubmed/26793323 http://dx.doi.org/10.12865/CHSJ.40.04.06 Text en Copyright © 2014, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
VELESCU, B.S.
UIVAROSI, VALENTINA
BUZESCU, ANCA
SARBU, I
IONESCU, ECATERINA
ANUTA, VALENTINA
Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex
title Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex
title_full Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex
title_fullStr Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex
title_full_unstemmed Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex
title_short Pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(IV)) complex
title_sort pharmacokinetic profile evaluation of di-μ-hydroxo-bis(quercetinatooxovanadium(iv)) complex
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709704/
https://www.ncbi.nlm.nih.gov/pubmed/26793323
http://dx.doi.org/10.12865/CHSJ.40.04.06
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