Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients

Purpose: To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis. Material and Methods: Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal populati...

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Detalles Bibliográficos
Autores principales: PĂDUREANU, V., STREAȚĂ, IOANA, IOANA, M., ȘURLIN, V., GEORGESCU, E.F., MĂRGINEAN, CRISTINA, SĂFTOIU, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709709/
https://www.ncbi.nlm.nih.gov/pubmed/26793321
http://dx.doi.org/10.12865/CHSJ.40.04.03
Descripción
Sumario:Purpose: To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis. Material and Methods: Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS – 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated. Results: We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis. Conclusion: In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism.

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