Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients

Purpose: To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis. Material and Methods: Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal populati...

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Autores principales: PĂDUREANU, V., STREAȚĂ, IOANA, IOANA, M., ȘURLIN, V., GEORGESCU, E.F., MĂRGINEAN, CRISTINA, SĂFTOIU, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709709/
https://www.ncbi.nlm.nih.gov/pubmed/26793321
http://dx.doi.org/10.12865/CHSJ.40.04.03
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author PĂDUREANU, V.
STREAȚĂ, IOANA
IOANA, M.
ȘURLIN, V.
GEORGESCU, E.F.
MĂRGINEAN, CRISTINA
SĂFTOIU, A.
author_facet PĂDUREANU, V.
STREAȚĂ, IOANA
IOANA, M.
ȘURLIN, V.
GEORGESCU, E.F.
MĂRGINEAN, CRISTINA
SĂFTOIU, A.
author_sort PĂDUREANU, V.
collection PubMed
description Purpose: To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis. Material and Methods: Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS – 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated. Results: We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis. Conclusion: In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism.
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spelling pubmed-47097092016-01-20 Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients PĂDUREANU, V. STREAȚĂ, IOANA IOANA, M. ȘURLIN, V. GEORGESCU, E.F. MĂRGINEAN, CRISTINA SĂFTOIU, A. Curr Health Sci J Original Paper Purpose: To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis. Material and Methods: Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS – 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated. Results: We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis. Conclusion: In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism. Medical University Publishing House Craiova 2014 2014-12-14 /pmc/articles/PMC4709709/ /pubmed/26793321 http://dx.doi.org/10.12865/CHSJ.40.04.03 Text en Copyright © 2014, Medical University Publishing House Craiova http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
PĂDUREANU, V.
STREAȚĂ, IOANA
IOANA, M.
ȘURLIN, V.
GEORGESCU, E.F.
MĂRGINEAN, CRISTINA
SĂFTOIU, A.
Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients
title Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients
title_full Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients
title_fullStr Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients
title_full_unstemmed Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients
title_short Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients
title_sort determination of inos-2087a>g polymorphism in acute pancreatitis patients
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709709/
https://www.ncbi.nlm.nih.gov/pubmed/26793321
http://dx.doi.org/10.12865/CHSJ.40.04.03
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