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The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis

Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation...

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Detalles Bibliográficos
Autores principales: Storoni, Mithu, Plant, Gordon T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709725/
https://www.ncbi.nlm.nih.gov/pubmed/26839705
http://dx.doi.org/10.1155/2015/681289
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author Storoni, Mithu
Plant, Gordon T.
author_facet Storoni, Mithu
Plant, Gordon T.
author_sort Storoni, Mithu
collection PubMed
description Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis. We review evidence that the ketogenic diet can improve mitochondrial function and discuss the potential of the ketogenic diet in treating progressive multiple sclerosis for which no treatment currently exists.
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spelling pubmed-47097252016-02-02 The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis Storoni, Mithu Plant, Gordon T. Mult Scler Int Review Article Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis. We review evidence that the ketogenic diet can improve mitochondrial function and discuss the potential of the ketogenic diet in treating progressive multiple sclerosis for which no treatment currently exists. Hindawi Publishing Corporation 2015 2015-12-29 /pmc/articles/PMC4709725/ /pubmed/26839705 http://dx.doi.org/10.1155/2015/681289 Text en Copyright © 2015 M. Storoni and G. T. Plant. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Storoni, Mithu
Plant, Gordon T.
The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis
title The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis
title_full The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis
title_fullStr The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis
title_full_unstemmed The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis
title_short The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis
title_sort therapeutic potential of the ketogenic diet in treating progressive multiple sclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709725/
https://www.ncbi.nlm.nih.gov/pubmed/26839705
http://dx.doi.org/10.1155/2015/681289
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