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The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis
Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709725/ https://www.ncbi.nlm.nih.gov/pubmed/26839705 http://dx.doi.org/10.1155/2015/681289 |
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author | Storoni, Mithu Plant, Gordon T. |
author_facet | Storoni, Mithu Plant, Gordon T. |
author_sort | Storoni, Mithu |
collection | PubMed |
description | Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis. We review evidence that the ketogenic diet can improve mitochondrial function and discuss the potential of the ketogenic diet in treating progressive multiple sclerosis for which no treatment currently exists. |
format | Online Article Text |
id | pubmed-4709725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47097252016-02-02 The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis Storoni, Mithu Plant, Gordon T. Mult Scler Int Review Article Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis. We review evidence that the ketogenic diet can improve mitochondrial function and discuss the potential of the ketogenic diet in treating progressive multiple sclerosis for which no treatment currently exists. Hindawi Publishing Corporation 2015 2015-12-29 /pmc/articles/PMC4709725/ /pubmed/26839705 http://dx.doi.org/10.1155/2015/681289 Text en Copyright © 2015 M. Storoni and G. T. Plant. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Storoni, Mithu Plant, Gordon T. The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis |
title | The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis |
title_full | The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis |
title_fullStr | The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis |
title_full_unstemmed | The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis |
title_short | The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis |
title_sort | therapeutic potential of the ketogenic diet in treating progressive multiple sclerosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709725/ https://www.ncbi.nlm.nih.gov/pubmed/26839705 http://dx.doi.org/10.1155/2015/681289 |
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