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In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer's disease, and epile...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709762/ https://www.ncbi.nlm.nih.gov/pubmed/26839720 http://dx.doi.org/10.1155/2016/9847696 |
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author | Pantazopoulos, Harry Berretta, Sabina |
author_facet | Pantazopoulos, Harry Berretta, Sabina |
author_sort | Pantazopoulos, Harry |
collection | PubMed |
description | Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer's disease, and epilepsy point to the involvement of ECM molecules such as chondroitin sulfate proteoglycans, Reelin, and matrix metalloproteases, as well as their cell surface receptors. In many of these disorders, PNN abnormalities have also been reported. In the context of the “quadripartite” synapse concept, that is, the functional unit composed of the pre- and postsynaptic terminals, glial processes, and ECM, and of the role that PNNs and ECM molecules play in regulating synaptic functions and plasticity, these findings resonate with one of the most well-replicated aspects of the pathology of psychiatric disorders, that is, synaptic abnormalities. Here we review the evidence for PNN/ECM-related pathology in these disorders, with particular emphasis on schizophrenia, and discuss the hypothesis that such pathology may significantly contribute to synaptic dysfunction. |
format | Online Article Text |
id | pubmed-4709762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47097622016-02-02 In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders Pantazopoulos, Harry Berretta, Sabina Neural Plast Review Article Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer's disease, and epilepsy point to the involvement of ECM molecules such as chondroitin sulfate proteoglycans, Reelin, and matrix metalloproteases, as well as their cell surface receptors. In many of these disorders, PNN abnormalities have also been reported. In the context of the “quadripartite” synapse concept, that is, the functional unit composed of the pre- and postsynaptic terminals, glial processes, and ECM, and of the role that PNNs and ECM molecules play in regulating synaptic functions and plasticity, these findings resonate with one of the most well-replicated aspects of the pathology of psychiatric disorders, that is, synaptic abnormalities. Here we review the evidence for PNN/ECM-related pathology in these disorders, with particular emphasis on schizophrenia, and discuss the hypothesis that such pathology may significantly contribute to synaptic dysfunction. Hindawi Publishing Corporation 2016 2015-12-29 /pmc/articles/PMC4709762/ /pubmed/26839720 http://dx.doi.org/10.1155/2016/9847696 Text en Copyright © 2016 H. Pantazopoulos and S. Berretta. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pantazopoulos, Harry Berretta, Sabina In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
title | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
title_full | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
title_fullStr | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
title_full_unstemmed | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
title_short | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
title_sort | in sickness and in health: perineuronal nets and synaptic plasticity in psychiatric disorders |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709762/ https://www.ncbi.nlm.nih.gov/pubmed/26839720 http://dx.doi.org/10.1155/2016/9847696 |
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