High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling

[Image: see text] Cryptococcus neoformans is one of the most important human fungal pathogens; however, no new therapies have been developed in over 50 years. Fungicidal activity is crucially important for an effective anticryptococal agent and, therefore, we screened 361,675 molecules against C. ne...

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Autores principales: Hartland, Kate, Pu, Jun, Palmer, Michelle, Dandapani, Sivaraman, Moquist, Philip N., Munoz, Benito, DiDone, Louis, Schreiber, Stuart L., Krysan, Damian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709821/
https://www.ncbi.nlm.nih.gov/pubmed/26807437
http://dx.doi.org/10.1021/acsinfecdis.5b00111

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