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Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland
The traditional Inuit diet in Greenland consists mainly of fish and marine mammals, rich in vitamin D. Vitamin D has anti-inflammatory capacity but markers of inflammation have been found to be high in Inuit living on a marine diet. Yet, the effect of vitamin D on inflammation in Inuit remains unset...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709837/ https://www.ncbi.nlm.nih.gov/pubmed/26793305 http://dx.doi.org/10.1017/jns.2015.33 |
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author | Schæbel, L. K. Bonefeld-Jørgensen, E. C. Laurberg, P. Vestergaard, H. Andersen, S. |
author_facet | Schæbel, L. K. Bonefeld-Jørgensen, E. C. Laurberg, P. Vestergaard, H. Andersen, S. |
author_sort | Schæbel, L. K. |
collection | PubMed |
description | The traditional Inuit diet in Greenland consists mainly of fish and marine mammals, rich in vitamin D. Vitamin D has anti-inflammatory capacity but markers of inflammation have been found to be high in Inuit living on a marine diet. Yet, the effect of vitamin D on inflammation in Inuit remains unsettled. This led us to investigate the association between vitamin D and markers of inflammation in a population with a high intake of a marine diet. We studied 535 Inuit and non-Inuit living in West and East Greenland. Information concerning dietary habits was obtained by interview-based FFQ. Blood samples were drawn for analysis of 25-hydroxyvitamin D, high-sensitivity C-reactive protein (hsCRP) and chitinase-3-like protein 1(YKL-40). Participants were divided into three groups based on degree of intake of the traditional Inuit diet. The diet groups (Inuit diet/mixed diet/imported foods) were associated with vitamin D levels in serum (74·2, 69·8 and 52·9 nm; P < 0·001), hsCRP (1·6, 1·4 and 1·3 mg/l; P = 0·002) and YKL-40 (130, 95 and 61 ng/ml; P < 0·001), respectively. YKL-40 level decreased with rising vitamin D level in Inuit (Inuit diet P = 0·002; mixed diet P = 0·011). YKL-40 was lower in groups with higher vitamin D levels after adjusting for other factors known to influence inflammation (P < 0·001). This was not seen for hsCRP. In conclusion, vitamin D and markers of inflammation vary in parallel with the intake of the marine Inuit diet. Vitamin D levels were inversely associated with YKL-40 levels, but no association with hsCRP was found. The hypothesised anti-inflammatory effect of vitamin D was not supported. Other factors in the marine diet may be speculated to influence inflammation. |
format | Online Article Text |
id | pubmed-4709837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47098372016-01-20 Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland Schæbel, L. K. Bonefeld-Jørgensen, E. C. Laurberg, P. Vestergaard, H. Andersen, S. J Nutr Sci Research Article The traditional Inuit diet in Greenland consists mainly of fish and marine mammals, rich in vitamin D. Vitamin D has anti-inflammatory capacity but markers of inflammation have been found to be high in Inuit living on a marine diet. Yet, the effect of vitamin D on inflammation in Inuit remains unsettled. This led us to investigate the association between vitamin D and markers of inflammation in a population with a high intake of a marine diet. We studied 535 Inuit and non-Inuit living in West and East Greenland. Information concerning dietary habits was obtained by interview-based FFQ. Blood samples were drawn for analysis of 25-hydroxyvitamin D, high-sensitivity C-reactive protein (hsCRP) and chitinase-3-like protein 1(YKL-40). Participants were divided into three groups based on degree of intake of the traditional Inuit diet. The diet groups (Inuit diet/mixed diet/imported foods) were associated with vitamin D levels in serum (74·2, 69·8 and 52·9 nm; P < 0·001), hsCRP (1·6, 1·4 and 1·3 mg/l; P = 0·002) and YKL-40 (130, 95 and 61 ng/ml; P < 0·001), respectively. YKL-40 level decreased with rising vitamin D level in Inuit (Inuit diet P = 0·002; mixed diet P = 0·011). YKL-40 was lower in groups with higher vitamin D levels after adjusting for other factors known to influence inflammation (P < 0·001). This was not seen for hsCRP. In conclusion, vitamin D and markers of inflammation vary in parallel with the intake of the marine Inuit diet. Vitamin D levels were inversely associated with YKL-40 levels, but no association with hsCRP was found. The hypothesised anti-inflammatory effect of vitamin D was not supported. Other factors in the marine diet may be speculated to influence inflammation. Cambridge University Press 2015-12-16 /pmc/articles/PMC4709837/ /pubmed/26793305 http://dx.doi.org/10.1017/jns.2015.33 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited |
spellingShingle | Research Article Schæbel, L. K. Bonefeld-Jørgensen, E. C. Laurberg, P. Vestergaard, H. Andersen, S. Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland |
title | Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland |
title_full | Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland |
title_fullStr | Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland |
title_full_unstemmed | Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland |
title_short | Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland |
title_sort | vitamin d-rich marine inuit diet and markers of inflammation – a population-based survey in greenland |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709837/ https://www.ncbi.nlm.nih.gov/pubmed/26793305 http://dx.doi.org/10.1017/jns.2015.33 |
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