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Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

BACKGROUND: Alzheimer’s disease (AD) is the most frequent form of dementia in the elderly and no effective treatment is currently available. The mechanisms triggering AD onset and progression are still imperfectly dissected. We aimed at deciphering the modifications occurring in vivo during the very...

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Detalles Bibliográficos
Autores principales:	Audrain, Mickael, Fol, Romain, Dutar, Patrick, Potier, Brigitte, Billard, Jean-Marie, Flament, Julien, Alves, Sandro, Burlot, Marie-Anne, Dufayet-Chaffaud, Gaelle, Bemelmans, Alexis-Pierre, Valette, Julien, Hantraye, Philippe, Déglon, Nicole, Cartier, Nathalie, Braudeau, Jérome
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709894/ https://www.ncbi.nlm.nih.gov/pubmed/26759118 http://dx.doi.org/10.1186/s13024-016-0070-y

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