Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance

Although mitogen-activated protein kinase kinase (MEK) is a key signaling molecule and a negative regulator of insulin action, it is still uncertain whether MEK can be a therapeutic target for amelioration of insulin resistance (IR) in type 2 diabetes (T2D) in vivo. To clarify whether MEK inhibition...

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Detalles Bibliográficos
Autores principales: Ueyama, Atsunori, Ban, Nobuhiro, Fukazawa, Masanori, Hirayama, Tohru, Takeda, Minako, Yata, Tatsuo, Muramatsu, Hiroyasu, Hoshino, Masaki, Yamamoto, Marii, Matsuo, Masao, Kawashima, Yuka, Iwase, Tatsuhiko, Kitazawa, Takehisa, Kushima, Youichi, Yamada, Yuichiro, Kawabe, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709921/
https://www.ncbi.nlm.nih.gov/pubmed/26839898
http://dx.doi.org/10.1155/2016/8264830

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