A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production

Aberrantly rearranged immunoglobulin (Ig) alleles are frequent. They are usually considered sterile and innocuous as a result of nonsense-mediated mRNA decay. However, alternative splicing can yield internally deleted proteins from such nonproductively V(D)J-rearranged loci. We show that nonsense co...

Descripción completa

Detalles Bibliográficos
Autores principales: Srour, Nivine, Chemin, Guillaume, Tinguely, Aurélien, Ashi, Mohamad Omar, Oruc, Zéliha, Péron, Sophie, Sirac, Christophe, Cogné, Michel, Delpy, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710196/
https://www.ncbi.nlm.nih.gov/pubmed/26666261
http://dx.doi.org/10.1084/jem.20131511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710196/
https://www.ncbi.nlm.nih.gov/pubmed/26666261
http://dx.doi.org/10.1084/jem.20131511

Ejemplares similares