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A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production

Aberrantly rearranged immunoglobulin (Ig) alleles are frequent. They are usually considered sterile and innocuous as a result of nonsense-mediated mRNA decay. However, alternative splicing can yield internally deleted proteins from such nonproductively V(D)J-rearranged loci. We show that nonsense co...

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Detalles Bibliográficos
Autores principales:	Srour, Nivine, Chemin, Guillaume, Tinguely, Aurélien, Ashi, Mohamad Omar, Oruc, Zéliha, Péron, Sophie, Sirac, Christophe, Cogné, Michel, Delpy, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710196/ https://www.ncbi.nlm.nih.gov/pubmed/26666261 http://dx.doi.org/10.1084/jem.20131511

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