Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles

t(8;21) is one of the most frequent chromosomal abnormalities observed in acute myeloid leukemia (AML). However, expression of AML1-ETO is not sufficient to induce transformation in vivo. Consistent with this observation, patients with this translocation harbor additional genetic abnormalities, sugg...

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Detalles Bibliográficos
Autores principales: Hatlen, Megan A., Arora, Kanika, Vacic, Vladimir, Grabowska, Ewa A., Liao, Willey, Riley-Gillis, Bridget, Oschwald, Dayna M., Wang, Lan, Joergens, Jacob E., Shih, Alan H., Rapaport, Franck, Gu, Shengqing, Voza, Francesca, Asai, Takashi, Neel, Benjamin G., Kharas, Michael G., Gonen, Mithat, Levine, Ross L., Nimer, Stephen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710200/
https://www.ncbi.nlm.nih.gov/pubmed/26666262
http://dx.doi.org/10.1084/jem.20150524

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