Cargando…

Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer

Mutations within the epidermal growth factor receptor (EGFR/erbB1/Her1) are often associated with tumorigenesis. In particular, a number of EGFR mutants that demonstrate ligand-independent signaling are common in non–small cell lung cancer (NSCLC), including kinase domain mutations L858R (also calle...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valley, Christopher C., Arndt-Jovin, Donna J., Karedla, Narain, Steinkamp, Mara P., Chizhik, Alexey I., Hlavacek, William S., Wilson, Bridget S., Lidke, Keith A., Lidke, Diane S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710239/ https://www.ncbi.nlm.nih.gov/pubmed/26337388 http://dx.doi.org/10.1091/mbc.E15-05-0269

Ejemplares similares

Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes
por: Salazar-Cavazos, Emanuel, et al.
Publicado: (2020)

Reaching out for signals: filopodia sense EGF and respond by directed retrograde transport of activated receptors
por: Lidke, Diane S., et al.
Publicado: (2005)

ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand-binding
por: Low-Nam, Shalini T., et al.
Publicado: (2011)

Sequential Superresolution Imaging of Multiple Targets Using a Single Fluorophore
por: Valley, Christopher C., et al.
Publicado: (2015)

EGFR transactivates RON to drive oncogenic crosstalk
por: Franco Nitta, Carolina, et al.
Publicado: (2021)

Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics
por: Schwartz, Samantha L., et al.
Publicado: (2017)

High-speed single molecule imaging datasets of membrane proteins in rat basophilic leukemia cells
por: Mazloom-Farsibaf, Hanieh, et al.
Publicado: (2020)

Quantitative cell biology: uniting disciplines to understand the cell
por: Lidke, Diane S.
Publicado: (2017)

Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1
por: Kanagy, William K., et al.
Publicado: (2022)

Optimal Aggregation of FcεRI with a Structurally Defined Trivalent Ligand Overrides Negative Regulation Driven by Phosphatases
por: Mahajan, Avanika, et al.
Publicado: (2014)

Multi-Color Quantum Dot Tracking Using a High-Speed Hyperspectral Line-Scanning Microscope
por: Cutler, Patrick J., et al.
Publicado: (2013)

Fluorogen-Activating Proteins Provide Tunable Labeling Densities for Tracking FcεRI Independent of IgE
por: Schwartz, Samantha L., et al.
Publicado: (2014)

Sequential super-resolution imaging using DNA strand displacement
por: Pallikkuth, Sandeep, et al.
Publicado: (2018)

Dual-color metal-induced and Förster resonance energy transfer for cell nanoscopy
por: Chizhik, Anna M., et al.
Publicado: (2018)

Effect of Phosphorylation on EGFR Dimer Stability Probed by Single-Molecule Dynamics and FRET/FLIM
por: Coban, Oana, et al.
Publicado: (2015)

Mast Cell Synapses and Exosomes: Membrane Contacts for Information Exchange
por: Carroll-Portillo, Amanda, et al.
Publicado: (2012)

Nanoscopic cell-wall architecture of an immunogenic ligand in Candida albicans during antifungal drug treatment
por: Lin, Jia, et al.
Publicado: (2016)

Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcεRI Aggregation and Structural Changes
por: Rinaldi, Derek A., et al.
Publicado: (2023)

Spatiotemporal Clustering of Repeated Super-Resolution Localizations via Linear Assignment Problem
por: Schodt, David J., et al.
Publicado: (2021)

Corrigendum: Spatiotemporal Clustering of Repeated Super-Resolution Localizations via Linear Assignment Problem
por: Schodt, David J., et al.
Publicado: (2022)

Application of Biophysical Techniques to Cellular and Molecular Oncology
por: Lidke, Diane S., et al.
Publicado: (2023)

Metal-Induced Energy Transfer (MIET) for Live-Cell Imaging with Fluorescent Proteins
por: Hauke, Lara, et al.
Publicado: (2023)

Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants
por: Park, Angela K.J., et al.
Publicado: (2015)

PD-L1 Expression in Mastocytosis
por: Williams, Margaret, et al.
Publicado: (2019)

Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling
por: Pascarelli, Stefano, et al.
Publicado: (2021)

Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy
por: DIBAJI, HASSAN, et al.
Publicado: (2023)

Tetraspanin CD82 drives Acute Myeloid Leukemia chemoresistance by modulating Protein Kinase C alpha and β1 integrin activation
por: Floren, Muskan, et al.
Publicado: (2020)

Fast, single-molecule localization that achieves theoretically minimum uncertainty
por: Smith, Carlas S., et al.
Publicado: (2010)

Tetraspanin CD82 Regulates the Spatiotemporal Dynamics of PKCα in Acute Myeloid Leukemia
por: Termini, Christina M., et al.
Publicado: (2016)

High-precision estimation of emitter positions using Bayesian grouping of localizations
por: Fazel, Mohamadreza, et al.
Publicado: (2022)

Effect of Spatial Inhomogeneities on the Membrane Surface on Receptor Dimerization and Signal Initiation
por: Kerketta, Romica, et al.
Publicado: (2016)

Orchestration of ErbB3 signaling through heterointeractions and homointeractions
por: McCabe Pryor, Meghan, et al.
Publicado: (2015)

Simultaneous multiple-emitter fitting for single molecule super-resolution imaging
por: Huang, Fang, et al.
Publicado: (2011)

Probability-based particle detection that enables threshold-free and robust in vivo single-molecule tracking
por: Smith, Carlas S., et al.
Publicado: (2015)

Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ
por: Travers, Timothy, et al.
Publicado: (2019)

Hidden in the crowd: primordial germ cells and somatic stem cells in the mesodermal posterior growth zone of the polychaete Platynereis dumerillii are two distinct cell populations
por: Rebscher, Nicole, et al.
Publicado: (2012)

Bcl-2 together with PI3K p110α regulates cell morphology and cell migration
por: Wan, G, et al.
Publicado: (2015)

Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules
por: Vleeshouwers, Ward, et al.
Publicado: (2021)

Dual-color superresolution microscopy reveals nanoscale organization of mechanosensory podosomes
por: van den Dries, K., et al.
Publicado: (2013)

Magnetic Nanoparticles as Mediators of Ligand-Free Activation of EGFR Signaling
por: Bharde, Atul A., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tqkkdbi2d03ptq680ohru9l476