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Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007

Diseases of zoonotic origin contribute to the burden of febrile illnesses in developing countries. We evaluated serologic evidence of exposure to Bacillus anthracis, Brucella spp., spotted fever group rickettsioses (SFGR), and typhus group rickettsioses (TGR) from samples of persons aged 15–64 years...

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Autores principales: Omballa, Victor O., Musyoka, Raymond N., Vittor, Amy Y., Wamburu, Kabura B., Wachira, Cyrus M., Waiboci, Lilian W., Abudo, Mamo U., Juma, Bonventure W., Kim, Andrea A., Montgomery, Joel M., Breiman, Robert F., Fields, Barry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710443/
https://www.ncbi.nlm.nih.gov/pubmed/26598574
http://dx.doi.org/10.4269/ajtmh.15-0320
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author Omballa, Victor O.
Musyoka, Raymond N.
Vittor, Amy Y.
Wamburu, Kabura B.
Wachira, Cyrus M.
Waiboci, Lilian W.
Abudo, Mamo U.
Juma, Bonventure W.
Kim, Andrea A.
Montgomery, Joel M.
Breiman, Robert F.
Fields, Barry S.
author_facet Omballa, Victor O.
Musyoka, Raymond N.
Vittor, Amy Y.
Wamburu, Kabura B.
Wachira, Cyrus M.
Waiboci, Lilian W.
Abudo, Mamo U.
Juma, Bonventure W.
Kim, Andrea A.
Montgomery, Joel M.
Breiman, Robert F.
Fields, Barry S.
author_sort Omballa, Victor O.
collection PubMed
description Diseases of zoonotic origin contribute to the burden of febrile illnesses in developing countries. We evaluated serologic evidence of exposure to Bacillus anthracis, Brucella spp., spotted fever group rickettsioses (SFGR), and typhus group rickettsioses (TGR) from samples of persons aged 15–64 years collected during a nationwide human immunodeficiency virus (HIV) serosurvey conducted in 2007 in Kenya. The seropositivity observed for pathogens was B. anthracis 11.3%, Brucella spp. 3.0%, SFGR 23.3%, and TGR 0.6%. On univariate analysis, seropositivity for each pathogen was significantly associated with the following risk factors: B. anthracis with province of residence; Brucella spp. with sex, education level, and wealth; SFGR with age, education level, wealth, and province of residence; and TGR with province of residence. On multivariate analysis, seropositivity remained significantly associated with wealth and province for B. anthracis; with sex and age for Brucella spp; and with sex, education level, and province of residence for SFGR whereas TGR had no significance. High IgG seropositivity to these zoonotic pathogens (especially, B. anthracis and SFGR) suggests substantial exposure. These pathogens should be considered in the differential diagnosis of febrile illness in Kenya.
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spelling pubmed-47104432016-01-19 Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007 Omballa, Victor O. Musyoka, Raymond N. Vittor, Amy Y. Wamburu, Kabura B. Wachira, Cyrus M. Waiboci, Lilian W. Abudo, Mamo U. Juma, Bonventure W. Kim, Andrea A. Montgomery, Joel M. Breiman, Robert F. Fields, Barry S. Am J Trop Med Hyg Articles Diseases of zoonotic origin contribute to the burden of febrile illnesses in developing countries. We evaluated serologic evidence of exposure to Bacillus anthracis, Brucella spp., spotted fever group rickettsioses (SFGR), and typhus group rickettsioses (TGR) from samples of persons aged 15–64 years collected during a nationwide human immunodeficiency virus (HIV) serosurvey conducted in 2007 in Kenya. The seropositivity observed for pathogens was B. anthracis 11.3%, Brucella spp. 3.0%, SFGR 23.3%, and TGR 0.6%. On univariate analysis, seropositivity for each pathogen was significantly associated with the following risk factors: B. anthracis with province of residence; Brucella spp. with sex, education level, and wealth; SFGR with age, education level, wealth, and province of residence; and TGR with province of residence. On multivariate analysis, seropositivity remained significantly associated with wealth and province for B. anthracis; with sex and age for Brucella spp; and with sex, education level, and province of residence for SFGR whereas TGR had no significance. High IgG seropositivity to these zoonotic pathogens (especially, B. anthracis and SFGR) suggests substantial exposure. These pathogens should be considered in the differential diagnosis of febrile illness in Kenya. The American Society of Tropical Medicine and Hygiene 2016-01-06 /pmc/articles/PMC4710443/ /pubmed/26598574 http://dx.doi.org/10.4269/ajtmh.15-0320 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Omballa, Victor O.
Musyoka, Raymond N.
Vittor, Amy Y.
Wamburu, Kabura B.
Wachira, Cyrus M.
Waiboci, Lilian W.
Abudo, Mamo U.
Juma, Bonventure W.
Kim, Andrea A.
Montgomery, Joel M.
Breiman, Robert F.
Fields, Barry S.
Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007
title Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007
title_full Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007
title_fullStr Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007
title_full_unstemmed Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007
title_short Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007
title_sort serologic evidence of the geographic distribution of bacterial zoonotic agents in kenya, 2007
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710443/
https://www.ncbi.nlm.nih.gov/pubmed/26598574
http://dx.doi.org/10.4269/ajtmh.15-0320
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