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Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain)
BACKGROUND: Several studies have reported decreases in birth size associated with exposure to organochlorine compounds (OCs), but uncertainties remain regarding the critical windows of prenatal exposure and the effects on fetal body segments. OBJECTIVE: We examined the relationship between prenatal...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710595/ https://www.ncbi.nlm.nih.gov/pubmed/26058084 http://dx.doi.org/10.1289/ehp.1408907 |
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author | Lopez-Espinosa, Maria-Jose Murcia, Mario Iñiguez, Carmen Vizcaino, Esther Costa, Olga Fernández-Somoano, Ana Basterrechea, Mikel Lertxundi, Aitana Guxens, Mònica Gascon, Mireia Goñi-Irigoyen, Fernando Grimalt, Joan O. Tardón, Adonina Ballester, Ferran |
author_facet | Lopez-Espinosa, Maria-Jose Murcia, Mario Iñiguez, Carmen Vizcaino, Esther Costa, Olga Fernández-Somoano, Ana Basterrechea, Mikel Lertxundi, Aitana Guxens, Mònica Gascon, Mireia Goñi-Irigoyen, Fernando Grimalt, Joan O. Tardón, Adonina Ballester, Ferran |
author_sort | Lopez-Espinosa, Maria-Jose |
collection | PubMed |
description | BACKGROUND: Several studies have reported decreases in birth size associated with exposure to organochlorine compounds (OCs), but uncertainties remain regarding the critical windows of prenatal exposure and the effects on fetal body segments. OBJECTIVE: We examined the relationship between prenatal OC concentrations and fetal anthropometry. METHODS: We measured 4,4´-dichlorodiphenyldichloroethylene (4,4´-DDE), hexachlorobenzene (HCB), and polychlorinated biphenyl (PCB) congeners (138, 153, and 180) in 2,369 maternal and 1,140 cord serum samples in four Spanish cohorts (2003–2008). We used linear mixed models to obtain longitudinal growth curves for estimated fetal weight (EFW), abdominal circumference (AC), biparietal diameter (BPD), and femur length (FL) adjusted by parental and fetal characteristics. We calculated standard deviation (SD) scores of growth at 0–12, 12–20, and 20–34 weeks of gestation as well as size at gestational week 34 for the four parameters. We studied the association between OCs and the fetal outcomes by cohort-specific linear models and subsequent meta-analyses. RESULTS: PCBs were associated with a reduction in AC up to mid-pregnancy, and BPD and FL from gestational week 20 onward. An inverse association was also found between HCB and AC growth in early pregnancy. The reduction of these parameters ranged from –4% to –2% for a doubling in the OC concentrations. No association between 4,4´-DDE and fetal growth was observed. CONCLUSIONS: To our knowledge, this is the first study to report an association between prenatal exposure to some PCBs and HCB and fetal growth: AC during the first two trimesters of pregnancy, and BPD and FL later in pregnancy. CITATION: Lopez-Espinosa MJ, Murcia M, Iñiguez C, Vizcaino E, Costa O, Fernández-Somoano A, Basterrechea M, Lertxundi A, Guxens M, Gascon M, Goñi-Irigoyen F, Grimalt JO, Tardón A, Ballester F. 2016. Organochlorine compounds and ultrasound measurements of fetal growth in the INMA cohort (Spain). Environ Health Perspect 124:157–163; http://dx.doi.org/10.1289/ehp.1408907 |
format | Online Article Text |
id | pubmed-4710595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-47105952016-01-20 Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain) Lopez-Espinosa, Maria-Jose Murcia, Mario Iñiguez, Carmen Vizcaino, Esther Costa, Olga Fernández-Somoano, Ana Basterrechea, Mikel Lertxundi, Aitana Guxens, Mònica Gascon, Mireia Goñi-Irigoyen, Fernando Grimalt, Joan O. Tardón, Adonina Ballester, Ferran Environ Health Perspect Children's Health BACKGROUND: Several studies have reported decreases in birth size associated with exposure to organochlorine compounds (OCs), but uncertainties remain regarding the critical windows of prenatal exposure and the effects on fetal body segments. OBJECTIVE: We examined the relationship between prenatal OC concentrations and fetal anthropometry. METHODS: We measured 4,4´-dichlorodiphenyldichloroethylene (4,4´-DDE), hexachlorobenzene (HCB), and polychlorinated biphenyl (PCB) congeners (138, 153, and 180) in 2,369 maternal and 1,140 cord serum samples in four Spanish cohorts (2003–2008). We used linear mixed models to obtain longitudinal growth curves for estimated fetal weight (EFW), abdominal circumference (AC), biparietal diameter (BPD), and femur length (FL) adjusted by parental and fetal characteristics. We calculated standard deviation (SD) scores of growth at 0–12, 12–20, and 20–34 weeks of gestation as well as size at gestational week 34 for the four parameters. We studied the association between OCs and the fetal outcomes by cohort-specific linear models and subsequent meta-analyses. RESULTS: PCBs were associated with a reduction in AC up to mid-pregnancy, and BPD and FL from gestational week 20 onward. An inverse association was also found between HCB and AC growth in early pregnancy. The reduction of these parameters ranged from –4% to –2% for a doubling in the OC concentrations. No association between 4,4´-DDE and fetal growth was observed. CONCLUSIONS: To our knowledge, this is the first study to report an association between prenatal exposure to some PCBs and HCB and fetal growth: AC during the first two trimesters of pregnancy, and BPD and FL later in pregnancy. CITATION: Lopez-Espinosa MJ, Murcia M, Iñiguez C, Vizcaino E, Costa O, Fernández-Somoano A, Basterrechea M, Lertxundi A, Guxens M, Gascon M, Goñi-Irigoyen F, Grimalt JO, Tardón A, Ballester F. 2016. Organochlorine compounds and ultrasound measurements of fetal growth in the INMA cohort (Spain). Environ Health Perspect 124:157–163; http://dx.doi.org/10.1289/ehp.1408907 National Institute of Environmental Health Sciences 2015-06-09 2016-01 /pmc/articles/PMC4710595/ /pubmed/26058084 http://dx.doi.org/10.1289/ehp.1408907 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Children's Health Lopez-Espinosa, Maria-Jose Murcia, Mario Iñiguez, Carmen Vizcaino, Esther Costa, Olga Fernández-Somoano, Ana Basterrechea, Mikel Lertxundi, Aitana Guxens, Mònica Gascon, Mireia Goñi-Irigoyen, Fernando Grimalt, Joan O. Tardón, Adonina Ballester, Ferran Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain) |
title | Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain) |
title_full | Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain) |
title_fullStr | Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain) |
title_full_unstemmed | Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain) |
title_short | Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain) |
title_sort | organochlorine compounds and ultrasound measurements of fetal growth in the inma cohort (spain) |
topic | Children's Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710595/ https://www.ncbi.nlm.nih.gov/pubmed/26058084 http://dx.doi.org/10.1289/ehp.1408907 |
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