Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics

BACKGROUND: Carcinogenic hexavalent chromium [Cr(VI)] requires cellular reduction to generate DNA damage. Metabolism of Cr(VI) by its principal reducer ascorbate (Asc) lacks a Cr(V) intermediate, which is abundant in reactions with a minor reducing agent, glutathione. Cultured cells are widely used...

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Detalles Bibliográficos
Autores principales: Luczak, Michal W., Green, Samantha E., Zhitkovich, Anatoly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710604/
https://www.ncbi.nlm.nih.gov/pubmed/25977998
http://dx.doi.org/10.1289/ehp.1409434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710604/
https://www.ncbi.nlm.nih.gov/pubmed/25977998
http://dx.doi.org/10.1289/ehp.1409434

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