A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome Pathways

BACKGROUND: Adverse outcome pathways (AOPs) link adverse effects in individuals or populations to a molecular initiating event (MIE) that can be quantified using in vitro methods. Practical application of AOPs in chemical-specific risk assessment requires incorporation of knowledge on exposure, alon...

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Detalles Bibliográficos
Autores principales: Phillips, Martin B., Leonard, Jeremy A., Grulke, Christopher M., Chang, Daniel T., Edwards, Stephen W., Brooks, Raina, Goldsmith, Michael-Rock, El-Masri, Hisham, Tan, Yu-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710605/
https://www.ncbi.nlm.nih.gov/pubmed/25978103
http://dx.doi.org/10.1289/ehp.1409450

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