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Glucose improves object-location binding in visual-spatial working memory

RATIONALE: There is evidence that glucose temporarily enhances cognition and that processes dependent on the hippocampus may be particularly sensitive. As the hippocampus plays a key role in binding processes, we examined the influence of glucose on memory for object-location bindings. OBJECTIVE: Th...

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Autores principales: Stollery, Brian, Christian, Leonie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710657/
https://www.ncbi.nlm.nih.gov/pubmed/26576942
http://dx.doi.org/10.1007/s00213-015-4125-5
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author Stollery, Brian
Christian, Leonie
author_facet Stollery, Brian
Christian, Leonie
author_sort Stollery, Brian
collection PubMed
description RATIONALE: There is evidence that glucose temporarily enhances cognition and that processes dependent on the hippocampus may be particularly sensitive. As the hippocampus plays a key role in binding processes, we examined the influence of glucose on memory for object-location bindings. OBJECTIVE: This study aims to study how glucose modifies performance on an object-location memory task, a task that draws heavily on hippocampal function. METHODS: Thirty-one participants received 30 g glucose or placebo in a single 1-h session. After seeing between 3 and 10 objects (words or shapes) at different locations in a 9 × 9 matrix, participants attempted to immediately reproduce the display on a blank 9 × 9 matrix. Blood glucose was measured before drink ingestion, mid-way through the session, and at the end of the session. RESULTS: Glucose significantly improves object-location binding (d = 1.08) and location memory (d = 0.83), but not object memory (d = 0.51). Increasing working memory load impairs object memory and object-location binding, and word-location binding is more successful than shape-location binding, but the glucose improvement is robust across all difficulty manipulations. Within the glucose group, higher levels of circulating glucose are correlated with better binding memory and remembering the locations of successfully recalled objects. CONCLUSIONS: The glucose improvements identified are consistent with a facilitative impact on hippocampal function. The findings are discussed in the context of the relationship between cognitive processes, hippocampal function, and the implications for glucose’s mode of action.
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spelling pubmed-47106572016-01-22 Glucose improves object-location binding in visual-spatial working memory Stollery, Brian Christian, Leonie Psychopharmacology (Berl) Original Investigation RATIONALE: There is evidence that glucose temporarily enhances cognition and that processes dependent on the hippocampus may be particularly sensitive. As the hippocampus plays a key role in binding processes, we examined the influence of glucose on memory for object-location bindings. OBJECTIVE: This study aims to study how glucose modifies performance on an object-location memory task, a task that draws heavily on hippocampal function. METHODS: Thirty-one participants received 30 g glucose or placebo in a single 1-h session. After seeing between 3 and 10 objects (words or shapes) at different locations in a 9 × 9 matrix, participants attempted to immediately reproduce the display on a blank 9 × 9 matrix. Blood glucose was measured before drink ingestion, mid-way through the session, and at the end of the session. RESULTS: Glucose significantly improves object-location binding (d = 1.08) and location memory (d = 0.83), but not object memory (d = 0.51). Increasing working memory load impairs object memory and object-location binding, and word-location binding is more successful than shape-location binding, but the glucose improvement is robust across all difficulty manipulations. Within the glucose group, higher levels of circulating glucose are correlated with better binding memory and remembering the locations of successfully recalled objects. CONCLUSIONS: The glucose improvements identified are consistent with a facilitative impact on hippocampal function. The findings are discussed in the context of the relationship between cognitive processes, hippocampal function, and the implications for glucose’s mode of action. Springer Berlin Heidelberg 2015-11-18 2016 /pmc/articles/PMC4710657/ /pubmed/26576942 http://dx.doi.org/10.1007/s00213-015-4125-5 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Investigation
Stollery, Brian
Christian, Leonie
Glucose improves object-location binding in visual-spatial working memory
title Glucose improves object-location binding in visual-spatial working memory
title_full Glucose improves object-location binding in visual-spatial working memory
title_fullStr Glucose improves object-location binding in visual-spatial working memory
title_full_unstemmed Glucose improves object-location binding in visual-spatial working memory
title_short Glucose improves object-location binding in visual-spatial working memory
title_sort glucose improves object-location binding in visual-spatial working memory
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710657/
https://www.ncbi.nlm.nih.gov/pubmed/26576942
http://dx.doi.org/10.1007/s00213-015-4125-5
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