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Impact Study: MK-0646 (Dalotuzumab), Insulin Growth Factor 1 Receptor Antibody Combined with Pemetrexed and Cisplatin in Stage IV Metastatic Non-squamous Lung Cancer

BACKGROUND: Insulin-like growth factor 1 receptor (IGF-1R) regulates cell growth, proliferation, and apoptosis. Adenocarcinoma and never-smokers have a higher expression of IGF-1R, which is associated with worse overall survival. Dalotuzumab-MK0646 (D) is a humanized monoclonal antibody that targets...

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Detalles Bibliográficos
Autores principales:	Huang, Chao H., Williamson, Stephen K., Neupane, Prakash, Taylor, Sarah A., Allen, Ace, Smart, Nora J., Uypeckcuat, Adelina M., Spencer, Sarah, Wick, Jo, Smith, Holly, Van Veldhuizen, Peter J., Kelly, Karen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710681/ https://www.ncbi.nlm.nih.gov/pubmed/26793618 http://dx.doi.org/10.3389/fonc.2015.00301

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