Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease

Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this arti...

Descripción completa

Detalles Bibliográficos
Autores principales: Parks, Olivia B., Pociask, Derek A., Hodzic, Zerina, Kolls, Jay K., Good, Misty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710696/
https://www.ncbi.nlm.nih.gov/pubmed/26793707
http://dx.doi.org/10.3389/fcell.2015.00085
_version_ 1782409843563298816
author Parks, Olivia B.
Pociask, Derek A.
Hodzic, Zerina
Kolls, Jay K.
Good, Misty
author_facet Parks, Olivia B.
Pociask, Derek A.
Hodzic, Zerina
Kolls, Jay K.
Good, Misty
author_sort Parks, Olivia B.
collection PubMed
description Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease.
format Online
Article
Text
id pubmed-4710696
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-47106962016-01-20 Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease Parks, Olivia B. Pociask, Derek A. Hodzic, Zerina Kolls, Jay K. Good, Misty Front Cell Dev Biol Cell and Developmental Biology Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease. Frontiers Media S.A. 2016-01-13 /pmc/articles/PMC4710696/ /pubmed/26793707 http://dx.doi.org/10.3389/fcell.2015.00085 Text en Copyright © 2016 Parks, Pociask, Hodzic, Kolls and Good. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Parks, Olivia B.
Pociask, Derek A.
Hodzic, Zerina
Kolls, Jay K.
Good, Misty
Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease
title Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease
title_full Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease
title_fullStr Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease
title_full_unstemmed Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease
title_short Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease
title_sort interleukin-22 signaling in the regulation of intestinal health and disease
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710696/
https://www.ncbi.nlm.nih.gov/pubmed/26793707
http://dx.doi.org/10.3389/fcell.2015.00085
work_keys_str_mv AT parksoliviab interleukin22signalingintheregulationofintestinalhealthanddisease
AT pociaskdereka interleukin22signalingintheregulationofintestinalhealthanddisease
AT hodziczerina interleukin22signalingintheregulationofintestinalhealthanddisease
AT kollsjayk interleukin22signalingintheregulationofintestinalhealthanddisease
AT goodmisty interleukin22signalingintheregulationofintestinalhealthanddisease

Ejemplares similares