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Redox-dependent regulation of epidermal growth factor receptor signaling
Tyrosine phosphorylation-dependent cell signaling represents a unique feature of multicellular organisms, and is important in regulation of cell differentiation and specialized cell functions. Multicellular organisms also contain a diverse family of NADPH oxidases (NOXs) that have been closely linke...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710793/ https://www.ncbi.nlm.nih.gov/pubmed/26722841 http://dx.doi.org/10.1016/j.redox.2015.12.002 |
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author | Heppner, David E. van der Vliet, Albert |
author_facet | Heppner, David E. van der Vliet, Albert |
author_sort | Heppner, David E. |
collection | PubMed |
description | Tyrosine phosphorylation-dependent cell signaling represents a unique feature of multicellular organisms, and is important in regulation of cell differentiation and specialized cell functions. Multicellular organisms also contain a diverse family of NADPH oxidases (NOXs) that have been closely linked with tyrosine kinase-based cell signaling and regulate tyrosine phosphorylation via reversible oxidation of cysteine residues that are highly conserved within many proteins involved in this signaling pathway. An example of redox-regulated tyrosine kinase signaling involves the epidermal growth factor receptor (EGFR), a widely studied receptor system with diverse functions in normal cell biology as well as pathologies associated with oxidative stress such as cancer. The purpose of this Graphical Redox Review is to highlight recently emerged concepts with respect to NOX-dependent regulation of this important signaling pathway. |
format | Online Article Text |
id | pubmed-4710793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-47107932016-02-10 Redox-dependent regulation of epidermal growth factor receptor signaling Heppner, David E. van der Vliet, Albert Redox Biol Graphical Review Tyrosine phosphorylation-dependent cell signaling represents a unique feature of multicellular organisms, and is important in regulation of cell differentiation and specialized cell functions. Multicellular organisms also contain a diverse family of NADPH oxidases (NOXs) that have been closely linked with tyrosine kinase-based cell signaling and regulate tyrosine phosphorylation via reversible oxidation of cysteine residues that are highly conserved within many proteins involved in this signaling pathway. An example of redox-regulated tyrosine kinase signaling involves the epidermal growth factor receptor (EGFR), a widely studied receptor system with diverse functions in normal cell biology as well as pathologies associated with oxidative stress such as cancer. The purpose of this Graphical Redox Review is to highlight recently emerged concepts with respect to NOX-dependent regulation of this important signaling pathway. Elsevier 2015-12-08 /pmc/articles/PMC4710793/ /pubmed/26722841 http://dx.doi.org/10.1016/j.redox.2015.12.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Graphical Review Heppner, David E. van der Vliet, Albert Redox-dependent regulation of epidermal growth factor receptor signaling |
title | Redox-dependent regulation of epidermal growth factor receptor signaling |
title_full | Redox-dependent regulation of epidermal growth factor receptor signaling |
title_fullStr | Redox-dependent regulation of epidermal growth factor receptor signaling |
title_full_unstemmed | Redox-dependent regulation of epidermal growth factor receptor signaling |
title_short | Redox-dependent regulation of epidermal growth factor receptor signaling |
title_sort | redox-dependent regulation of epidermal growth factor receptor signaling |
topic | Graphical Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710793/ https://www.ncbi.nlm.nih.gov/pubmed/26722841 http://dx.doi.org/10.1016/j.redox.2015.12.002 |
work_keys_str_mv | AT heppnerdavide redoxdependentregulationofepidermalgrowthfactorreceptorsignaling AT vandervlietalbert redoxdependentregulationofepidermalgrowthfactorreceptorsignaling |