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Characteristics and Patterns of Metastatic Disease from Chordoma

Chordoma is a rare, slow-growing malignant tumor arising from notochordal remnants. A retrospective review of patient records at two major referral centers was undertaken to assess the incidence, location, and prognostic factors of metastatic disease from chordoma. 219 patients with chordoma (1962–2...

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Autores principales: Young, Victoria A., Curtis, Kevin M., Temple, H. Thomas, Eismont, Frank J., DeLaney, Thomas F., Hornicek, Francis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710904/
https://www.ncbi.nlm.nih.gov/pubmed/26843835
http://dx.doi.org/10.1155/2015/517657
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author Young, Victoria A.
Curtis, Kevin M.
Temple, H. Thomas
Eismont, Frank J.
DeLaney, Thomas F.
Hornicek, Francis J.
author_facet Young, Victoria A.
Curtis, Kevin M.
Temple, H. Thomas
Eismont, Frank J.
DeLaney, Thomas F.
Hornicek, Francis J.
author_sort Young, Victoria A.
collection PubMed
description Chordoma is a rare, slow-growing malignant tumor arising from notochordal remnants. A retrospective review of patient records at two major referral centers was undertaken to assess the incidence, location, and prognostic factors of metastatic disease from chordoma. 219 patients with chordoma (1962–2009) were identified. 39 patients (17.8%) developed metastatic disease, most frequently to lung (>50%). Median survival from the time of initial diagnosis was 130.4 months for patients who developed metastatic disease and 159.3 months for those who did not (P = 0.05). Metastatic disease was most common in the youngest patients (P = 0.07), and it was 2.5 times more frequent among patients with local recurrence (26.3%) than in those without (10.8%) (P = 0.003). Patient survival with metastatic disease was highly variable, and it was dependent on both the location of the tumor primary and the site of metastasis. Metastasis to distal bone was the most rapid to develop and had the worst prognosis.
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spelling pubmed-47109042016-02-03 Characteristics and Patterns of Metastatic Disease from Chordoma Young, Victoria A. Curtis, Kevin M. Temple, H. Thomas Eismont, Frank J. DeLaney, Thomas F. Hornicek, Francis J. Sarcoma Clinical Study Chordoma is a rare, slow-growing malignant tumor arising from notochordal remnants. A retrospective review of patient records at two major referral centers was undertaken to assess the incidence, location, and prognostic factors of metastatic disease from chordoma. 219 patients with chordoma (1962–2009) were identified. 39 patients (17.8%) developed metastatic disease, most frequently to lung (>50%). Median survival from the time of initial diagnosis was 130.4 months for patients who developed metastatic disease and 159.3 months for those who did not (P = 0.05). Metastatic disease was most common in the youngest patients (P = 0.07), and it was 2.5 times more frequent among patients with local recurrence (26.3%) than in those without (10.8%) (P = 0.003). Patient survival with metastatic disease was highly variable, and it was dependent on both the location of the tumor primary and the site of metastasis. Metastasis to distal bone was the most rapid to develop and had the worst prognosis. Hindawi Publishing Corporation 2015 2015-12-30 /pmc/articles/PMC4710904/ /pubmed/26843835 http://dx.doi.org/10.1155/2015/517657 Text en Copyright © 2015 Victoria A. Young et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Young, Victoria A.
Curtis, Kevin M.
Temple, H. Thomas
Eismont, Frank J.
DeLaney, Thomas F.
Hornicek, Francis J.
Characteristics and Patterns of Metastatic Disease from Chordoma
title Characteristics and Patterns of Metastatic Disease from Chordoma
title_full Characteristics and Patterns of Metastatic Disease from Chordoma
title_fullStr Characteristics and Patterns of Metastatic Disease from Chordoma
title_full_unstemmed Characteristics and Patterns of Metastatic Disease from Chordoma
title_short Characteristics and Patterns of Metastatic Disease from Chordoma
title_sort characteristics and patterns of metastatic disease from chordoma
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710904/
https://www.ncbi.nlm.nih.gov/pubmed/26843835
http://dx.doi.org/10.1155/2015/517657
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