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High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots

Proteolytic stability in gastrointestinal tract and blood plasma is the major obstacle for oral peptide drug development. Inhibitor cystine knots (ICKs) are linear cystine knot peptides which have multifunctional properties and could become promising drug scaffolds. ProTx-I, ProTx-II, GTx1-15, and G...

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Detalles Bibliográficos
Autores principales:	Kikuchi, Kyoko, Sugiura, Mika, Kimura, Tadashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710912/ https://www.ncbi.nlm.nih.gov/pubmed/26843868 http://dx.doi.org/10.1155/2015/537508

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