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Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era

Visceral leishmaniasis (VL) is the most devastating parasitic infection worldwide causing high morbidity and mortality. Clinical presentation of VL ranges from asymptomatic or subclinical infection to severe and complicated symptomatic disease. A major challenge in the clinical management of VL is t...

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Autores principales: Singh, Om Prakash, Sundar, Shyam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710934/
https://www.ncbi.nlm.nih.gov/pubmed/26843964
http://dx.doi.org/10.1155/2015/239469
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author Singh, Om Prakash
Sundar, Shyam
author_facet Singh, Om Prakash
Sundar, Shyam
author_sort Singh, Om Prakash
collection PubMed
description Visceral leishmaniasis (VL) is the most devastating parasitic infection worldwide causing high morbidity and mortality. Clinical presentation of VL ranges from asymptomatic or subclinical infection to severe and complicated symptomatic disease. A major challenge in the clinical management of VL is the weakness of health systems in disease endemic regions. People affected by VL mostly present to primary health care centers (PHCs), often late in their therapeutic itinerary. PHC physicians face a major challenge: they do not deal with a single disease issue but with patients presenting with complaints pointing to several diagnostic possibilities. Risk exists when some patients having less clinical manifestations are misdiagnosed. Therefore, field based accurate, sensitive, and cost effective rapid diagnostic tools that can detect disease in its mildest form are essential for effective control and reaching the goal of VL elimination. In this review, we discuss the current status and challenges of various diagnostic tools for the diagnosis of VL and assess their application in resource poor settings.
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spelling pubmed-47109342016-02-03 Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era Singh, Om Prakash Sundar, Shyam J Parasitol Res Review Article Visceral leishmaniasis (VL) is the most devastating parasitic infection worldwide causing high morbidity and mortality. Clinical presentation of VL ranges from asymptomatic or subclinical infection to severe and complicated symptomatic disease. A major challenge in the clinical management of VL is the weakness of health systems in disease endemic regions. People affected by VL mostly present to primary health care centers (PHCs), often late in their therapeutic itinerary. PHC physicians face a major challenge: they do not deal with a single disease issue but with patients presenting with complaints pointing to several diagnostic possibilities. Risk exists when some patients having less clinical manifestations are misdiagnosed. Therefore, field based accurate, sensitive, and cost effective rapid diagnostic tools that can detect disease in its mildest form are essential for effective control and reaching the goal of VL elimination. In this review, we discuss the current status and challenges of various diagnostic tools for the diagnosis of VL and assess their application in resource poor settings. Hindawi Publishing Corporation 2015 2015-12-30 /pmc/articles/PMC4710934/ /pubmed/26843964 http://dx.doi.org/10.1155/2015/239469 Text en Copyright © 2015 O. P. Singh and S. Sundar. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Singh, Om Prakash
Sundar, Shyam
Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era
title Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era
title_full Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era
title_fullStr Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era
title_full_unstemmed Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era
title_short Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era
title_sort developments in diagnosis of visceral leishmaniasis in the elimination era
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710934/
https://www.ncbi.nlm.nih.gov/pubmed/26843964
http://dx.doi.org/10.1155/2015/239469
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